Expression of hypoxia-inducible factor-1 alpha in the cutaneous lesions of BALB/c mice infected with Leishmania amazonensis

dc.creatorArrais-Silva, WW
dc.creatorPaffaro, VA
dc.creatorYamada, AT
dc.creatorGiorgio, S
dc.date2005
dc.dateFEB
dc.date2014-11-18T03:37:34Z
dc.date2015-11-26T16:50:28Z
dc.date2014-11-18T03:37:34Z
dc.date2015-11-26T16:50:28Z
dc.date.accessioned2018-03-28T23:37:14Z
dc.date.available2018-03-28T23:37:14Z
dc.identifierExperimental And Molecular Pathology. Academic Press Inc Elsevier Science, v. 78, n. 1, n. 49, n. 54, 2005.
dc.identifier0014-4800
dc.identifierWOS:000226078800007
dc.identifier10.1016/j.yexmp.2004.09.002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66478
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/66478
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66478
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275734
dc.descriptionThe hypoxia-inducible factor-1alpha (HIF-1alpha) is expressed in response to hypoxia and has been recently demonstrated in a variety of cells such as tumor cells and tumor-associated macrophages. Several characteristics of leishmanial lesions in humans and in animal models, such as microcirculation impairment, metabolic demand for leukocyte infiltration into infected tissue, parasite proliferation, and secondary bacterial infection, are strong indications of a hypoxic microenvironment in the lesions. We evaluated HIF-1alpha expression in the cutaneous lesions of BALB/c mice during Leishmania amazonensis infection. Immunohistochemical analyses of the lesions demonstrated, only in the later stages of infection when the lesion size is maximal and parasite burden is enormous and massive numbers of recruited macrophages and ulcers are observed, positive HIF-1alpha-infected cells throughout the lesions. HIF-1alpha is expressed mainly in the cytoplasm and around parasites inside the parasitophorous vacuoles of macrophages. This is the first evidence that macrophages in the microenvironment of lesions caused by a parasite produce a hypoxia-inducible factor. (C) 2004 Elsevier Inc. All rights reserved.
dc.description78
dc.description1
dc.description49
dc.description54
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationExperimental And Molecular Pathology
dc.relationExp. Mol. Pathol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectLeishmania amazonensis
dc.subjectamastigotes
dc.subjectmurine leishmaniasis
dc.subjectchronic cutaneous lesions
dc.subjectparasitic diseases
dc.subjectmacrophage
dc.subjectparasitophorous vacuoles
dc.subjectimmunohistochemistry studies
dc.subjecthypoxia-inducible factor-1 alpha
dc.subjecthypoxia
dc.subjectFactor-i
dc.subjectMacrophages
dc.subjectHif-1-alpha
dc.subjectActivation
dc.subjectApoptosis
dc.subjectWounds
dc.subjectCells
dc.subjectHif-1
dc.titleExpression of hypoxia-inducible factor-1 alpha in the cutaneous lesions of BALB/c mice infected with Leishmania amazonensis
dc.typeArtículos de revistas


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