Secretory immunoglobulin A in saliva of women with oral and genital HPV infection

dc.creatorGoncalves, AKS
dc.creatorGiraldo, P
dc.creatorBarros-Mazon, S
dc.creatorGondo, ML
dc.creatorAmaral, RL
dc.creatorJacyntho, C
dc.date2006
dc.dateFEB 1
dc.date2014-11-18T03:36:46Z
dc.date2015-11-26T16:50:28Z
dc.date2014-11-18T03:36:46Z
dc.date2015-11-26T16:50:28Z
dc.date.accessioned2018-03-28T23:37:13Z
dc.date.available2018-03-28T23:37:13Z
dc.identifierEuropean Journal Of Obstetrics Gynecology And Reproductive Biology. Elsevier Ireland Ltd, v. 124, n. 2, n. 227, n. 231, 2006.
dc.identifier0301-2115
dc.identifierWOS:000235348200019
dc.identifier10.1016/j.ejogrb.2005.06.028
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71291
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71291
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71291
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275733
dc.descriptionSecretory IgA contributes towards the protection of mucosal surfaces against invading microorganisms. Objectives: Quantify secretory IgA titers in the saliva of women with HPV in the oropharynx and/or in the genital area. Subjects and methods: Seventy women with clinical genital HPV lesions and 70 women without HPV infection were tested for oral HPV DNA and the levels of total IgA in their saliva. One millilitre of saliva was collected, centrifuged and stored at -80 degrees C for the measurement of secretory IgA by nephelometry technique. A pool of oral pharyngeal cells was collected for HPV identification by polymerase chain reaction. Results: Oral HPV PCR was positive in 29 (21%) women (26 women with genital HPV and only 3 women without genital HPV). Titers of secretory IgA were extremely lower in-patients with HPV DNA in the oropharynx when compared to HPV negative women (P < 0.0001). Genital HPV and smoking were also associated to low levels of total sIgA in saliva (p < 0.01). After multivariable analyses only the presence of HPV in the oral cavity and/or in genital area, but not smoking, was related to low levels of total secreton IgA. Conclusion: Women with low levels of total secretory IgA could be more susceptible to having their oral mucosa colonized by HPV. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
dc.description124
dc.description2
dc.description227
dc.description231
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationEuropean Journal Of Obstetrics Gynecology And Reproductive Biology
dc.relationEur. J. Obstet. Gynecol. Reprod. Biol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjecthuman papillomavirus
dc.subjectsexually transmitted disease
dc.subjectsecretory IgA
dc.subjectmucousa immunity
dc.subjectvaginal and oral infection
dc.subjectCervical Intraepithelial Neoplasia
dc.subjectHuman Papillomavirus Infection
dc.subjectMessenger-rna Expression
dc.subjectVirus-like Particles
dc.subjectMucosal Iga
dc.subjectPlasma Iga
dc.subjectImmunization
dc.titleSecretory immunoglobulin A in saliva of women with oral and genital HPV infection
dc.typeArtículos de revistas


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