In vitro studies of anticandidal activity of goniothalamin enantiomers

dc.creatorMartins, CVB
dc.creatorde Resende, MA
dc.creatorda Silva, DL
dc.creatorMagalhaes, TFF
dc.creatorModolo, LV
dc.creatorPilli, RA
dc.creatorde Fatima, A
dc.date2009
dc.dateOCT
dc.date2014-11-18T03:24:37Z
dc.date2015-11-26T16:50:23Z
dc.date2014-11-18T03:24:37Z
dc.date2015-11-26T16:50:23Z
dc.date.accessioned2018-03-28T23:37:09Z
dc.date.available2018-03-28T23:37:09Z
dc.identifierJournal Of Applied Microbiology. Wiley-blackwell Publishing, Inc, v. 107, n. 4, n. 1279, n. 1286, 2009.
dc.identifier1364-5072
dc.identifierWOS:000269730300024
dc.identifier10.1111/j.1365-2672.2009.04307.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69412
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69412
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69412
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275712
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionAims: The antifungal activity of (R)-goniothalamin (1) and (S)-goniothalamin (ent-1) was evaluated against six Candida species. The in vitro effect of these compounds on yeast adhesion to human buccal epithelial cells (BEC) and Candida albicans and C. dubliniensis biofilms progression were also investigated. Methods and Results: Yeast susceptibility was evaluated by broth microdilution assay and showed that ent-1 exhibited higher potency against all fungal clinical isolated when compared to compound 1. Compounds 1 and ent-1 were as potent as fluconazole in inhibiting the adhesion of C. albicans and C. dubliniensis to BEC. XTT-reducing assay and scanning electron microscopy revealed that 1 and ent-1 were twice as potent as fluconazole in the inhibition of yeast biofilms progression. Conclusions: Our findings indicate that compounds 1 and ent-1 are potent anticandidal agents. Significance and Impact of the Study: This study highlights goniothalamin enantiomers as promising lead compounds for the design of new antifungal with inhibitory activity on yeast adhesion and biofilm progression.
dc.description107
dc.description4
dc.description1279
dc.description1286
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherWiley-blackwell Publishing, Inc
dc.publisherMalden
dc.publisherEUA
dc.relationJournal Of Applied Microbiology
dc.relationJ. Appl. Microbiol.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectadhesion
dc.subjectantifungal activity
dc.subjectbiofilm
dc.subjectgoniothalamin
dc.subjectnatural products
dc.subjectCandida-albicans Biofilms
dc.subjectEpithelial-cells
dc.subjectAntifungal Activity
dc.subjectCytotoxic Activity
dc.subjectNatural-products
dc.subjectDrug Development
dc.subjectStyryl-lactones
dc.subjectOral Candidosis
dc.subjectDubliniensis
dc.subjectFluconazole
dc.titleIn vitro studies of anticandidal activity of goniothalamin enantiomers
dc.typeArtículos de revistas


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