EFFECT OF PROPRANOLOL AND NIFEDIPINE ON INVITRO FLUID ABSORPTION BY THE ISOLATED PERFUSED PROXIMAL CONVOLUTED TUBULE OF THE RABBIT

dc.creatorFIGUEIREDO, JF
dc.creatorFALKENSTEIN, D
dc.date1991
dc.date2014-07-30T17:09:19Z
dc.date2015-11-26T16:49:54Z
dc.date2014-07-30T17:09:19Z
dc.date2015-11-26T16:49:54Z
dc.date.accessioned2018-03-28T23:36:39Z
dc.date.available2018-03-28T23:36:39Z
dc.identifierBrazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 24, n. 12, n. 1265, n. 1268, 1991.
dc.identifier0100-879X
dc.identifierWOS:A1991GZ98500010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64244
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64244
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275584
dc.descriptionThe inhibition of fluid absorption (Jv) by the antiarrhythmic and antihypertensive drugs propranolol and nifedipine, which increase cytosolic Ca2+ concentration, was studied using the isolated rabbit proximal convoluted tubule perfused in vitro. Proximal convoluted tubules were perfused and bathed with a modified Krebs-Henseleit solution containing bovine serum albumin. Jv was measured after a 30-min control period, after 40 min with either 0.1 mM propranolol or 1.0 mM nifedipine on the peritubular side and after a 40-min recovery period. Both drugs inhibited Jv (58% propranolol, and 21% nifedipine). The 40-min recovery period was sufficient to reverse the effect of nifedipine, but propranolol-treated tubules (N = 6) only reached 78% of the control Jv value. These results demonstrate that antiarrhythmic and antihypertensive drugs are powerful inhibitors of net fluid absorption by exerting a direct effect on proximal or distal tubule cells, thus acting like "locak diuretics".
dc.description24
dc.description12
dc.description1265
dc.description1268
dc.languageen
dc.publisherAssoc Bras Divulg Cientifica
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationBrazilian Journal Of Medical And Biological Research
dc.relationBrazilian J. Med. Biol. Res.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectPROXIMAL CONVOLUTED TUBULES
dc.subjectPROPRANOLOL
dc.subjectNIFEDIPINE
dc.subjectTUBULE FLUID ABSORPTION
dc.subjectCytosolic Calcium
dc.subjectVerapamil
dc.subjectCa
dc.titleEFFECT OF PROPRANOLOL AND NIFEDIPINE ON INVITRO FLUID ABSORPTION BY THE ISOLATED PERFUSED PROXIMAL CONVOLUTED TUBULE OF THE RABBIT
dc.typeArtículos de revistas


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