Neocortical Atrophy in Machado-Joseph Disease: A Longitudinal Neuroimaging Study

dc.creatorD'Abreu, A
dc.creatorFranca, MC
dc.creatorYasuda, CL
dc.creatorCampos, BAG
dc.creatorLopes-Cendes, I
dc.creatorCendes, F
dc.date2012
dc.dateJUL
dc.date2014-07-30T17:09:02Z
dc.date2015-11-26T16:49:44Z
dc.date2014-07-30T17:09:02Z
dc.date2015-11-26T16:49:44Z
dc.date.accessioned2018-03-28T23:36:30Z
dc.date.available2018-03-28T23:36:30Z
dc.identifierJournal Of Neuroimaging. Wiley-blackwell, v. 22, n. 3, n. 285, n. 291, 2012.
dc.identifier1051-2284
dc.identifierWOS:000306293300014
dc.identifier10.1111/j.1552-6569.2011.00614.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64202
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64202
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275545
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBACKGROUND/PURPOSE Previous imaging studies in the Machado-Joseph disease (MJD/SCA3) have mostly concentrated on the cerebellum and brainstem. Our goal was to perform a whole brain longitudinal evaluation. METHODS We included 45 patients and 51 controls, who underwent two brain magnetic resonance imaging and magnetic resonance spectroscopy (mean interval of 12.5 +/- 1.5 months). We used voxel-based morphometry (VBM) and the MarsBar analysis toolbox to extract grey matter density (GMD) values from regions of interest. We used a linear regression model and a general linear model to correlate GMD with clinical markers, and paired t-test for the longitudinal evaluation. RESULTS We observed decreased GMD (P < .01) at frontal, parietal, temporal and occipital lobes, subcortical grey matter, cerebellum, and brainstem. White matter atrophy was restricted to the cerebellum. Age, CAG, and disease duration predicted GMD in different areas, but age and CAG were the most important predictors. The longitudinal analysis failed to demonstrate changes. Changes in regions other than the cerebellum appeared to contribute significantly to the final International Cooperative Ataxia Rating Scale score. CONCLUSION We confirmed cortical involvement in MJD/SCA3. The most important factors in predicting GMD were age and CAG. The lack of progression of atrophy may indicate floor effect and/or short duration of follow-up.
dc.description22
dc.description3
dc.description285
dc.description291
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationJournal Of Neuroimaging
dc.relationJ. Neuroimaging
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectSpinocerebellar ataxia type 3
dc.subjectMachado-Joseph disease
dc.subjectvoxel-based morphometry
dc.subjectspectroscopy
dc.subjectcortical atrophy
dc.subjectAtaxia Rating-scale
dc.subjectResonance-imaging Findings
dc.subjectVoxel-based Morphometry
dc.subjectWhite-matter
dc.subjectBrain-stem
dc.subjectCag Repeat
dc.subjectDegeneration
dc.subjectDisorder
dc.subjectType-3
dc.subjectSystem
dc.titleNeocortical Atrophy in Machado-Joseph Disease: A Longitudinal Neuroimaging Study
dc.typeArtículos de revistas


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