Hydroxyurea promotes the reduction of spontaneous BFU-e to normal levels in SS and S/beta thalassemic patients

dc.creatorBincoletto, C
dc.creatorPerlingeiro, RCR
dc.creatorSaad, STO
dc.creatorCosta, FF
dc.creatorQueiroz, MLS
dc.date2001
dc.date2014-07-30T17:59:46Z
dc.date2015-11-26T16:49:25Z
dc.date2014-07-30T17:59:46Z
dc.date2015-11-26T16:49:25Z
dc.date.accessioned2018-03-28T23:36:08Z
dc.date.available2018-03-28T23:36:08Z
dc.identifierHemoglobin. Marcel Dekker Inc, v. 25, n. 1, n. 1, n. 7, 2001.
dc.identifier0363-0269
dc.identifierWOS:000170050300001
dc.identifier10.1081/HEM-100103064
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69044
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69044
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275453
dc.descriptionWe have studied the effects of hydroxyurea on growth and differentiation of early erythroid progenitor cells (BFU-e) from peripheral blood of sickle cell disease patients (five SS and two Hb S/beta -thalassemia) in the presence or absence of exogenous stimulating factors. When the mononuclear cells from the sickle cell disease patients were cultured at diagnosis (before hydroxyurea treatment), there was an increased number of BFU-e in relation to controls (p < 0.05, Wilcoxon test) when cells were grown in the presence or absence of 5637 conditioned medium and erythropoietin. Colonies that developed in the absence of added growth factors were considered "spontaneous". A significant difference was observed after hydroxyurea treatment in the number of BFU-e obtained in the presence and absence of stimulus, with a higher reduction in the spontaneous BFU-e number. As expected, there was an increased Hb F level in these patients when compared with their pretreatment levels. There was no correlation between spontaneous BFU-e and hemoglobin levels in all patients studied.
dc.description25
dc.description1
dc.description1
dc.description7
dc.languageen
dc.publisherMarcel Dekker Inc
dc.publisherNew York
dc.publisherEUA
dc.relationHemoglobin
dc.relationHemoglobin
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectSickle-cell-anemia
dc.subjectFetal Hemoglobin Production
dc.subjectAcute Myeloblastic-leukemia
dc.subjectAcute Myeloid-leukemia
dc.subjectAutonomous Growth
dc.subjectReduced Survival
dc.subjectDisease
dc.subjectExpression
dc.subjectInduction
dc.subjectProliferation
dc.titleHydroxyurea promotes the reduction of spontaneous BFU-e to normal levels in SS and S/beta thalassemic patients
dc.typeArtículos de revistas


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