Chemical profile of meta-chlorophenylpiperazine (m-CPP) in ecstasy tablets by easy ambient sonic-spray ionization, X-ray fluorescence, ion mobility mass spectrometry and NMR

dc.creatorRomao, W
dc.creatorLalli, PM
dc.creatorFranco, MF
dc.creatorSanvido, G
dc.creatorSchwab, NV
dc.creatorLanaro, R
dc.creatorCosta, JL
dc.creatorSabino, BD
dc.creatorBueno, MIMS
dc.creatorde Sa, GF
dc.creatorDaroda, RJ
dc.creatorde Souza, V
dc.creatorEberlin, MN
dc.date2011
dc.dateJUL
dc.date2014-07-30T16:52:20Z
dc.date2015-11-26T16:49:19Z
dc.date2014-07-30T16:52:20Z
dc.date2015-11-26T16:49:19Z
dc.date.accessioned2018-03-28T23:36:00Z
dc.date.available2018-03-28T23:36:00Z
dc.identifierAnalytical And Bioanalytical Chemistry. Springer Heidelberg, v. 400, n. 9, n. 3053, n. 3064, 2011.
dc.identifier1618-2642
dc.identifierWOS:000291037800038
dc.identifier10.1007/s00216-011-4883-9
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63027
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63027
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275417
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionMeta-chlorophenylpiperazine (m-CPP) is a new illicit drug that has been sold as ecstasy tablets. Easy ambient sonic-spray ionization mass spectrometry (EASI-MS) and X-ray fluorescence spectrometry (XRF) are shown to provide relatively simple and selective screening tools to distinguish m-CPP tablets from tablets containing amphetamines (mainly 3,4-methylenedioxymethamphetamine (MDMA)). EASI-MS detects the active ingredients in their protonated forms: [m-CPP + H](+) of m/z 197, [MDMA + H](+) of m/z 194, and [2MDMA + HCl + H](+) of m/z 423 and other ions from excipients directly on the tablet surface, providing distinct chemical fingerprints. XRF identifies Cl, K, Ca, Fe, and Cu as inorganic ingredients present in the m-CPP tablets. In contrast, higher Cl concentrations and a more diverse set of elements (P, Cl, Ca, Fe, Cu, Zn, Pt, V, Hf, Ti, Pt, and Zr) were found in MDMA tablets. Principal component analysis applied to XRF data arranged samples in three groups: m-CPP tablets (four samples), MDMA tablets (twenty three samples), and tablets with no active ingredients (three samples). The EASI-MS and XRF techniques were also evaluated to quantify m-CPP in ecstasy tablets, with concentrations ranging from 4 to 40 mg of m-CPP per tablets. The m-CPP could only be differentiated from its isomers (o-CPP and for the three isomers p-CPP) by traveling wave ion mobility mass spectrometry and NMR measurements.
dc.description400
dc.description9
dc.description3053
dc.description3064
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.descriptionFINEP
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2009/07168-9, 2007/54357-6]
dc.descriptionCNPq [576183/2008-3]
dc.descriptionFAPERJ [E-26/190.060/2008]
dc.languageen
dc.publisherSpringer Heidelberg
dc.publisherHeidelberg
dc.publisherAlemanha
dc.relationAnalytical And Bioanalytical Chemistry
dc.relationAnal. Bioanal. Chem.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectDrug monitoring/drug screening
dc.subjectAmbient mass spectrometry/EASI-MS
dc.subjectForensics/toxicology
dc.subjectMetals/heavy metals
dc.subjectX-ray spectroscopy (XPS vertical bar XRF vertical bar EDX)
dc.subjectNMR/ESR
dc.subjectDesorption Electrospray-ionization
dc.subjectLiquid-chromatography
dc.subjectSynchrotron-radiation
dc.subjectElemental Analysis
dc.subjectHigh-throughput
dc.subjectPlasma
dc.subjectSpectroscopy
dc.subjectTrazodone
dc.subjectGas
dc.subjectOligosaccharides
dc.titleChemical profile of meta-chlorophenylpiperazine (m-CPP) in ecstasy tablets by easy ambient sonic-spray ionization, X-ray fluorescence, ion mobility mass spectrometry and NMR
dc.typeArtículos de revistas


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