EFFECT OF GLUCOSE AND K+ DEPOLARIZATION ON CYTOSOLIC FREE CA2+ IN CULTURED NEONATAL ISLETS

dc.creatorBOSCHERO, AC
dc.creatorBORDIN, S
dc.creatorPLASMAN, PO
dc.creatorHERCHUELZ, A
dc.date1992
dc.dateFEB
dc.date2014-07-30T17:05:38Z
dc.date2015-11-26T16:48:54Z
dc.date2014-07-30T17:05:38Z
dc.date2015-11-26T16:48:54Z
dc.date.accessioned2018-03-28T23:35:27Z
dc.date.available2018-03-28T23:35:27Z
dc.identifierHormone And Metabolic Research. Georg Thieme Verlag, v. 24, n. 2, n. 51, n. 52, 1992.
dc.identifier0018-5043
dc.identifierWOS:A1992HM59500001
dc.identifier10.1055/s-2007-1003253
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63921
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63921
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275291
dc.descriptionIn cultured neonatal islet cells, glucose (16.7 mM) and K+ (50 mM) increased cytosolic free Ca2+ ([Ca2+]i). The increments in [Ca2+]i induced by either glucose or K+ were similar to those obtained in cultured adult islet cells but only half of that recorded in freshly isolated adult islet cells. These data indicate that, in neonatal islet cells, the reduced insulin release in response to glucose is associated with a diminished increase in [Ca2+]i. This reduced insulin response may not solely be due to an impaired regulation of the ATP-sensitive K+ channels as previously suggested. It may also result from some alteration in the process of Ca2+ inflow through voltage-sensitive Ca2+ channels.
dc.description24
dc.description2
dc.description51
dc.description52
dc.languageen
dc.publisherGeorg Thieme Verlag
dc.publisherStuttgart
dc.publisherAlemanha
dc.relationHormone And Metabolic Research
dc.relationHorm. Metab. Res.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectPANCREATIC B-CELL
dc.subjectINSULIN RELEASE
dc.subjectNEONATAL ISLETS
dc.subjectCA2+ CHANNELS
dc.subjectCYTOSOLIC FREE CA2+
dc.subjectPancreatic-islets
dc.subjectInsulin Release
dc.subjectRat Islets
dc.subjectFetal
dc.subjectStimulation
dc.subjectCells
dc.titleEFFECT OF GLUCOSE AND K+ DEPOLARIZATION ON CYTOSOLIC FREE CA2+ IN CULTURED NEONATAL ISLETS
dc.typeArtículos de revistas


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