dc.creatorGameiro, J
dc.creatorNagib, P
dc.creatorVerinaud, L
dc.date2010
dc.dateJUL-SEP
dc.date2014-11-18T01:12:59Z
dc.date2015-11-26T16:48:43Z
dc.date2014-11-18T01:12:59Z
dc.date2015-11-26T16:48:43Z
dc.date.accessioned2018-03-28T23:35:13Z
dc.date.available2018-03-28T23:35:13Z
dc.identifierCell Adhesion & Migration. Landes Bioscience, v. 4, n. 3, n. 382, n. 390, 2010.
dc.identifier1933-6918
dc.identifierWOS:000208234800012
dc.identifier10.4161/cam.4.3.11789
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/72552
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/72552
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/72552
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1275229
dc.descriptionThe thymus plays a crucial role in the development of T lymphocytes by providing an inductive microenvironment in which committed progenitors undergo proliferation, T-cell receptor gene rearrangements and thymocyte differentiate into mature T cells. The thymus microenvironment forms a complex network of interaction that comprises non lymphoid cells (e.g., thymic epithelial cells, TEC), cytokines, chemokines, extracellular matrix elements (ECM), matrix metalloproteinases and other soluble proteins. The thymic epithelial meshwork is the major component of the thymic microenvironment, both morphologically and phenotypically limiting heterogeneous regions in thymic lobules and fulfilling an important role during specific stages of T-cell maturation. The process starts when bone marrow-derived lymphocyte precursors arrive at the outer cortical region of the thymic gland and begin to mature into functional T lymphocytes that will finally exit the thymus and populate the peripheral lymphoid organs. During their journey inside the thymus, thymocytes must interact with stromal cells (and their soluble products) and extracellular matrix proteins to receive appropriate signals for survival, proliferation and differentiation. The crucial components of the thymus microenvironment, and their complex interactions during the T-cell maturation process are summarized here with the objective of contributing to a better understanding of the function of the thymus, as well as assisting in the search for new therapeutic approaches to improve the immune response in various pathological conditions.
dc.description4
dc.description3
dc.description382
dc.description390
dc.languageen
dc.publisherLandes Bioscience
dc.publisherAustin
dc.publisherEUA
dc.relationCell Adhesion & Migration
dc.relationCelll Adhes. Migr.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectthymus
dc.subjectT-cell maturation
dc.subjectthymic microenvironment
dc.subjectthymocyte differantiation
dc.subjectchemokines
dc.subjectextracellular matrix
dc.subjectthymic nurse cells
dc.subjectmetalloproteinases
dc.titleThe thymus microenvironment in regulating thymocyte differentiation
dc.typeArtículos de revistas


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