| dc.creator | Vinagre, AM | |
| dc.creator | Collares, EF | |
| dc.date | 2013 | |
| dc.date | SEP | |
| dc.date | 2014-07-30T17:29:54Z | |
| dc.date | 2015-11-26T16:47:49Z | |
| dc.date | 2014-07-30T17:29:54Z | |
| dc.date | 2015-11-26T16:47:49Z | |
| dc.date.accessioned | 2018-03-28T23:34:05Z | |
| dc.date.available | 2018-03-28T23:34:05Z | |
| dc.identifier | Brazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 46, n. 9, n. 735, n. 738, 2013. | |
| dc.identifier | 0100-879X | |
| dc.identifier | WOS:000324930400002 | |
| dc.identifier | 10.1590/1414-431X20132975 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66090 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/66090 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1274958 | |
| dc.description | Dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At) delay liquid gastric emptying (GE) in rats. We evaluated adrenergic participation in this phenomenon in a study in male Wistar rats (250-300 g) pretreated subcutaneously with guanethidine (GUA), 100 mg.kg(-1).day(-1), or vehicle (V) for 2 days before experimental treatments. Other groups of animals were pretreated intravenously (iv) 15 min before treatment with V, prazosin (PRA; 1 mg/kg), yohimbine (YOH; 3 mg/kg), or propranolol (PRO; 4 mg/kg), or with intracerebroventricular (icv) administration of 25 mu g PRO or V. The groups were treated iv with saline or with 240 mu mol/kg Dp, AA, or At. GE was determined 10 min later by measuring the percentage of gastric retention (% GR) of saline labeled with phenol red 10 min after gavage. % GR (mean +/- SE, n=8) indicated that GUA abolished the effect of Dp (GUA vs V=31.7 +/- 1.6 vs 47.1 +/- 2.3%) and of At (33.2 +/- 2.3 vs 54.7 +/- 3.6%) on GE and significantly reduced the effect of AA (48.1 +/- 3.2 vs 67.2 +/- 3.1%). PRA and YOH did not modify the effect of the drugs. % GR (mean +/- SE, n=8) indicated that iv, but not icv, PRO abolished the effect of Dp (PRO vs V=29.1 +/- 1.7 vs 46.9 +/- 2.7%) and At (30.5 +/- 1.7 vs 49 +/- 3.2%) and significantly reduced the effect of AA (48.4 +/- 2.6 vs 59.5 +/- 3.1%). These data suggest activation of peripheral beta-adrenoceptors in the delayed GE induced by phenylpyrazolone derivatives. | |
| dc.description | 46 | |
| dc.description | 9 | |
| dc.description | 735 | |
| dc.description | 738 | |
| dc.description | Fundo de Apoio ao Ensino | |
| dc.description | a Pesquisa e Extensao (FAEPEX) | |
| dc.description | Universidade Estadual de Campinas, Campinas, SP, Brasil | |
| dc.language | en | |
| dc.publisher | Assoc Bras Divulg Cientifica | |
| dc.publisher | Sao Paulo | |
| dc.publisher | Brasil | |
| dc.relation | Brazilian Journal Of Medical And Biological Research | |
| dc.relation | Brazilian J. Med. Biol. Res. | |
| dc.rights | aberto | |
| dc.source | Web of Science | |
| dc.subject | Gastric emptying | |
| dc.subject | Dipyrone | |
| dc.subject | 4-Aminoantipyrine | |
| dc.subject | Antipyrine | |
| dc.subject | Sympathetic nervous system | |
| dc.subject | Adrenergic receptors | |
| dc.subject | Central-nervous-system | |
| dc.subject | Mechanisms | |
| dc.subject | Restraint | |
| dc.subject | Motility | |
| dc.subject | Subtypes | |
| dc.subject | Stress | |
| dc.title | Evidence for the involvement of peripheral beta-adrenoceptors in delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats | |
| dc.type | Artículos de revistas | |
