Quality of life and acute toxicity of radiotherapy in women with gynecologic cancer: a prospective longitudinal study

dc.creatorVaz, AF
dc.creatorPinto-Neto, AM
dc.creatorConde, DM
dc.creatorCosta-Paiva, L
dc.creatorMorais, SS
dc.creatorEsteves, SB
dc.date2008
dc.dateSEP
dc.date2014-11-17T23:21:14Z
dc.date2015-11-26T16:47:31Z
dc.date2014-11-17T23:21:14Z
dc.date2015-11-26T16:47:31Z
dc.date.accessioned2018-03-28T23:33:42Z
dc.date.available2018-03-28T23:33:42Z
dc.identifierArchives Of Gynecology And Obstetrics. Springer Heidelberg, v. 278, n. 3, n. 215, n. 223, 2008.
dc.identifier0932-0067
dc.identifierWOS:000257912300003
dc.identifier10.1007/s00404-007-0549-4
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58550
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58550
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58550
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274886
dc.descriptionObjective To investigate the incidence of acute toxicity of radiotherapy, evaluate quality of life (QOL) and identify its predictors in a cohort of gynecologic cancer patients. Methods A longitudinal prospective study was conducted including 107 women between the ages of 18 and 75 years with cervical or endometrial cancer. Acute toxicity was evaluated according to the Common Toxicity Criteria and the Radiotherapy Oncology Group toxicity criteria. QOL was measured with World Health Organization's Quality of Life instrument-abbreviated version (WHOQOL-BREF) before and at completion of radiotherapy and during the first clinical follow-up visit. QOL scores were assessed by ANOVA for repeat measures. Percentage variation of QOL scores from the time before radiotherapy to the first clinical visit was compared with control variables by the Wilcoxon test. Multiple linear regression analysis was used to identify predictors of QOL. Results Ninety-five women completed the three QOL assessments. The incidence of acute toxicity was 93.5% and the most common complaint was lower gastrointestinal (79.6%). A significant increase in QOL scores was observed in the physical and psychological domains, as well as general health and overall QOL. Upper gastrointestinal toxicity (p = 0.043) and surgery (p = 0.027) negatively affected general health, while improvement in vaginal bleeding (p = 0.047) positively influenced general health. Conclusion A high incidence of acute toxicity of radiotherapy was observed. At the completion of treatment, QOL improved in gynecologic cancer patients. Women with upper gastrointestinal toxicity and history of surgery are at risk for having a worse QOL.
dc.description278
dc.description3
dc.description215
dc.description223
dc.languageen
dc.publisherSpringer Heidelberg
dc.publisherHeidelberg
dc.publisherAlemanha
dc.relationArchives Of Gynecology And Obstetrics
dc.relationArch. Gynecol. Obstet.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectquality of life
dc.subjectgynecologic cancer
dc.subjectWHOQOL-BREF questionnaire
dc.subjectradiotherapy
dc.subjectside effects
dc.subjectOncology Group Rtog
dc.subjectEndometrial Cancer
dc.subjectCervical-cancer
dc.subjectPostoperative Radiotherapy
dc.subjectUterine-cancer
dc.subjectBreast-cancer
dc.subjectWhoqol-bref
dc.subjectStage-i
dc.subjectImpact
dc.subjectSurvivors
dc.titleQuality of life and acute toxicity of radiotherapy in women with gynecologic cancer: a prospective longitudinal study
dc.typeArtículos de revistas


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