Does the criterion for prostate biopsy indication impact its accuracy? A prospective population-based outpatient clinical setting study

dc.creatorReis, LO
dc.creatorZani, EL
dc.creatorAlonso, JC
dc.creatorSimoes, FA
dc.creatorRejowski, RF
dc.creatorFerreira, U
dc.date2011
dc.dateJAN
dc.date2014-07-30T14:49:24Z
dc.date2015-11-26T16:47:25Z
dc.date2014-07-30T14:49:24Z
dc.date2015-11-26T16:47:25Z
dc.date.accessioned2018-03-28T23:33:35Z
dc.date.available2018-03-28T23:33:35Z
dc.identifierActas Urologicas Espanolas. Ene Ediciones Sl, v. 35, n. 1, n. 10, n. 14, 2011.
dc.identifier0210-4806
dc.identifierWOS:000290356900004
dc.identifier10.1016/j.acuro.2010.06.011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62430
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62430
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274856
dc.descriptionIntroduction: Prostate specific antigen (PSA) and digital rectal examination (DRE) are the main tests for initial prostate investigation; there is no consensus about the best criterion for prostate biopsies. We aim to check the accuracy of different criteria in this context including PSA derivatives to detect prostate cancer. Material and methods: Four different criteria for indication of prostate biopsy were compared: (A) PSA-density (>15 ng/ml/cc); (B) PSA > 2,5ng/ml; (C) PSA-velocity (> 0.7 ng/ml/year); (D) free/total PSA ratio (<15%). All biopsies and histopathological examinations were performed by the same urologist and pathologist, respectively. Results: The study was performed on 180 consecutive biopsies with 37.7% overall cancer detection rate: 29 (16.1%) performed following criterion A, 42(23.3%) criterion B, 65(36.1%) criterion C and 44 (24.4%) criterion D. Based on PSA criteria alone, the predictive positive value (PPV) was 37.9% for criterion A, 33.3% for B, 32.3% for C and 50.0% for criterion D, respectively, (p > 0.05). Associating positive DRE with changed PSA, the PPV increased to 50%, 50%, 43.9% and 68.2% for criteria A, B, C and D, respectively (p > 0.05). In univariate analysis, DRE (positive versus negative), PSA level (>10 ng/ml versus <4.0 ng/ml), free/total PSA ratio (<10% versus >15%) and age were associated with PC. In multivariate analysis only positive DRE was associated with prostate cancer. Conclusions: All the criteria of PSA derivatives are complementary and useful predictors of cancer risk. However, a positive DRE increased the PPV of PSA derivatives. New tools are needed to improve the accuracy of prostate cancer detection. (C) 2010 AEU. Published by Elsevier Espana, S.L. All rights reserved.
dc.description35
dc.description1
dc.description10
dc.description14
dc.languagees
dc.publisherEne Ediciones Sl
dc.publisherMadrid
dc.publisherEspanha
dc.relationActas Urologicas Espanolas
dc.relationActas Urol. Esp.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectProstate cancer
dc.subjectDiagnosis
dc.subjectProstate biopsy
dc.subjectAccuracy
dc.subjectPSA derivatives
dc.subjectDigital rectal examination
dc.subjectDigital Rectal Examination
dc.subjectPercent Free-psa
dc.subjectAntigen Velocity
dc.subjectCancer Detection
dc.subjectDensity
dc.subjectNg/ml
dc.subjectMen
dc.subjectTrial
dc.subjectThreshold
dc.subjectMortality
dc.titleDoes the criterion for prostate biopsy indication impact its accuracy? A prospective population-based outpatient clinical setting study
dc.typeArtículos de revistas


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