Doxycycline ameliorates the dystrophic phenotype of skeletal and cardiac muscles in mdx mice

dc.creatorPereira, JA
dc.creatorTaniguti, APT
dc.creatorMatsumura, C
dc.creatorMarques, MJ
dc.creatorNeto, HS
dc.date2012
dc.dateSEP
dc.date2014-07-30T17:04:50Z
dc.date2015-11-26T16:46:24Z
dc.date2014-07-30T17:04:50Z
dc.date2015-11-26T16:46:24Z
dc.date.accessioned2018-03-28T23:32:14Z
dc.date.available2018-03-28T23:32:14Z
dc.identifierMuscle & Nerve. Wiley-blackwell, v. 46, n. 3, n. 400, n. 406, 2012.
dc.identifier0148-639X
dc.identifierWOS:000308084500012
dc.identifier10.1002/mus.23331
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63482
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63482
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274510
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionIntroduction: We examined whether doxycycline, an antibiotic member of the tetracycline family, improves the histopathology and muscle function in mdx mice, the experimental model of DMD. Methods: Doxycycline was administered for 36 days (starting on postnatal day 0) and for 9 months (starting at 8 months of age) in drinking water. Histopathological, biochemical (creatine kinase), and functional (forelimb muscle grip strength) parameters were evaluated in limb, diaphragm, and cardiac muscle. Results: Doxycycline significantly minimized the dystrophic phenotype of skeletal and cardiac muscles and improved forelimb muscle strength. The drug protected muscle fibers against myonecrosis and reduced inflammation. Furthermore, it slowed the progression of myocardial fibrosis. Conclusions: This study provides evidence that doxycycline may be a potential therapeutic agent for DMD. Muscle Nerve 46: 400406, 2012
dc.description46
dc.description3
dc.description400
dc.description406
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFAPESP [04/15526-9, 08/58491-1]
dc.descriptionCNPq [301306/2010-9, 302006/2009-5]
dc.descriptionCNPq [140557/07-5]
dc.descriptionFAPESP [08/54775-5]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcardiac muscle
dc.subjectDMD
dc.subjectdoxycycline
dc.subjectdystrophy
dc.subjectmdx
dc.subjectskeletal muscle
dc.subjectDuchenne Muscular-dystrophy
dc.subjectDeficient Muscle
dc.subjectCardiomyopathy
dc.subjectMouse
dc.subjectProgression
dc.subjectPathology
dc.subjectNecrosis
dc.subjectDegeneration
dc.subjectInhibition
dc.subjectStrategies
dc.titleDoxycycline ameliorates the dystrophic phenotype of skeletal and cardiac muscles in mdx mice
dc.typeArtículos de revistas


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