Nuclear alterations of cells and atypical metaplastic cells in cervical smears are predictive criteria of high-grade cervical intraepithelial neoplasia

dc.creatorDufloth, RM
dc.creatorMessias-Silva, SM
dc.creatorAndrade, LA
dc.creatordi Loreto, C
dc.creatorMunhoz, DM
dc.creatorZeferino, LC
dc.date2005
dc.date2014-07-30T14:48:49Z
dc.date2015-11-26T16:45:39Z
dc.date2014-07-30T14:48:49Z
dc.date2015-11-26T16:45:39Z
dc.date.accessioned2018-03-28T23:31:18Z
dc.date.available2018-03-28T23:31:18Z
dc.identifierEuropean Journal Of Gynaecological Oncology. I R O G Canada, Inc, v. 26, n. 2, n. 186, n. 190, 2005.
dc.identifier0392-2936
dc.identifierWOS:000228533500012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62177
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62177
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274286
dc.descriptionDiagnoses based on the screening of cervical smears show low interobserver reproducibility and are frequently discordant with the final histological diagnosis. The aim of this study was to identify which of the cytomorphologic criteria used in the screening of cervical smears were most predictive of the histopathological grades of cervical intraepithelial neoplasia. The abnormal cervical smears of 206 women were reviewed blindly according to 22 pre-established cytomorphological criteria. Colposcopic evaluation was carried out in all cases. The marked presence of several nuclear criteria frequently found together in the same smear was associated with high grade intraepithelial neoplasia regardless of the presence of any other criteria. On the other hand, when the nuclear criteria were less evident, the cluster of criteria related to metaplastic cells was predictive of a diagnosis of high-grade intraepithelial neoplasia. Focusing on selected cytological criteria can aggregate predictive value to cervical smear diagnoses.
dc.description26
dc.description2
dc.description186
dc.description190
dc.languageen
dc.publisherI R O G Canada, Inc
dc.publisherMontreal
dc.publisherCanadá
dc.relationEuropean Journal Of Gynaecological Oncology
dc.relationEur. J. Gynaecol. Oncol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectcervical smear
dc.subjectmetaplastic cells
dc.subjectpredictive value
dc.subjectscreening
dc.subjectcervical cancer
dc.subjectPapanicolaou Smears
dc.subjectUndetermined Significance
dc.subjectSquamous-cells
dc.subjectAbnormal-cells
dc.subjectCytology
dc.subjectLesions
dc.subjectAscus
dc.subjectReproducibility
dc.subjectProgression
dc.subjectFeatures
dc.titleNuclear alterations of cells and atypical metaplastic cells in cervical smears are predictive criteria of high-grade cervical intraepithelial neoplasia
dc.typeArtículos de revistas


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