Evaluation of Radioprotective Effect of Pilocarpine Ingestion on Salivary Glands

dc.creatorPimentel, MJ
dc.creatorBatista, MMV
dc.creatorAraujo, M
dc.creatorGomes, DQ
dc.creatorDa Costa, LJ
dc.date2014
dc.dateAPR
dc.date2014-07-30T17:28:08Z
dc.date2015-11-26T16:45:18Z
dc.date2014-07-30T17:28:08Z
dc.date2015-11-26T16:45:18Z
dc.date.accessioned2018-03-28T23:30:52Z
dc.date.available2018-03-28T23:30:52Z
dc.identifierAnticancer Research. Int Inst Anticancer Research, v. 34, n. 4, n. 1993, n. 1999, 2014.
dc.identifier0250-7005
dc.identifier1791-7530
dc.identifierWOS:000334089200065
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65890
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65890
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274176
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThere is controversy concerning the effect of pilocarpine in the reversal of radio-induced xerostomia; however, the tests are usually performed at the end of radiotherapy. The present study evaluated the radioprotective effects of pilocarpine when ingested during radiation treatment. Eleven patients (recently diagnosed with head and neck cancer who were not undergoing radiotherapy) were divided into two groups: the control group (saline solution intake n=6) and the pilocarpine-treated (5 mg pilocarpine three times daily, n=5) group, in a prospective and double-blinded study. For five weeks, oral conditions, unstimulated salivary flow and stimulated saliva flow were collected weekly, with the first collection occurring prior to radiation therapy. As early as the second week, the control group exhibited oral complications and greater reduction in salivary flow rate. At the end of the study, the pilocarpine-treated group presented mean values of salivary flow greater than those of the control group. Pilocarpine intake applied simultaneously with radiotherapy demonstrated encouraging results with regard to lowering salivary flow reduction and incidence of xerostomia, as well as of oral complications.
dc.descriptionO TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE DEZEMBRO DE 2014.
dc.description34
dc.description4
dc.descriptionSI
dc.description1993
dc.description1999
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherInt Inst Anticancer Research
dc.publisherAthens
dc.publisherGrécia
dc.relationAnticancer Research
dc.relationAnticancer Res.
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectRadiotherapy
dc.subjectpilocarpine
dc.subjectxerostomia
dc.subjectOral Pilocarpine
dc.subjectPostirradiation Xerostomia
dc.subjectNeck-cancer
dc.subjectRadiotherapy
dc.subjectHead
dc.subjectEfficacy
dc.subjectTherapy
dc.subjectFlow
dc.titleEvaluation of Radioprotective Effect of Pilocarpine Ingestion on Salivary Glands
dc.typeArtículos de revistas


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