Nongenotoxic effects and a reduction of the DXR-induced genotoxic effects of Helianthus annuus Linne (sunflower) seeds revealed by micronucleus assays in mouse bone marrow

dc.creatorBoriollo, MFG
dc.creatorSouza, LS
dc.creatorResende, MR
dc.creatorda Silva, TA
dc.creatorOliveira, NDS
dc.creatorResck, MCC
dc.creatorDias, CTD
dc.creatorFiorini, JE
dc.date2014
dc.dateAPR 2
dc.date2014-07-30T14:48:31Z
dc.date2015-11-26T16:45:16Z
dc.date2014-07-30T14:48:31Z
dc.date2015-11-26T16:45:16Z
dc.date.accessioned2018-03-28T23:30:50Z
dc.date.available2018-03-28T23:30:50Z
dc.identifierBmc Complementary And Alternative Medicine. Biomed Central Ltd, v. 14, 2014.
dc.identifier1472-6882
dc.identifierWOS:000334470500002
dc.identifier10.1186/1472-6882-14-121
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61994
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61994
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274166
dc.descriptionBackground: This research evaluated the genotoxicity of oil and tincture of H. annuus L. seeds using the micronucleus assay in bone marrow of mice. The interaction between these preparations and the genotoxic effects of doxorubicin (DXR) was also analysed (antigenotoxicity test). Methods: Experimental groups were evaluated at 24-48 h post treatment with N-Nitroso-N-ethylurea (positive control - NEU), DXR (chemotherapeutic), NaCl (negative control), a sunflower tincture (THALS) and two sources of sunflower oils (POHALS and FOHALS). Antigenotoxic assays were carried out using the sunflower tincture and oils separately and in combination with NUE or DXR. Results: For THALS, analysis of the MNPCEs showed no significant differences between treatment doses (250-2,000 mg.Kg(-1)) and NaCl. A significant reduction in MNPCE was observed when THALS (2,000 mg.Kg(-1)) was administered in combination with DXR (5 mg.Kg(-1)). For POHALS or FOHALS, analysis of the MNPCEs also showed no significant differences between treatment doses (250-2,000 mg.Kg(-1)) and NaCl. However, the combination DXR + POHALS (2,000 mg.Kg(-1)) or DXR + FOHALS (2,000 mg.Kg(-1)) not contributed to the MNPCEs reduction. Conclusions: This research suggests absence of genotoxicity of THALS, dose-, time- and sex-independent, and its combination with DXR can reduce the genotoxic effects of DXR. POHALS and FOHALS also showed absence of genotoxicity, but their association with DXR showed no antigenotoxic effects.
dc.description14
dc.descriptionRede Mineira de Ensaios Toxicologicos e Farmacologicos de Produtos Terapeuticos (REDE MINEIRA TOXIFAR)
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.languageen
dc.publisherBiomed Central Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationBmc Complementary And Alternative Medicine
dc.relationBMC Complement. Altern. Med.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectBone marrow
dc.subjectHelianthus annuus L. (sunflower)
dc.subjectMicronucleus assay
dc.subjectRodents
dc.subjectTincture
dc.subjectOil
dc.subjectProstate-cancer Risk
dc.subjectFatty-acids
dc.subjectDietary-fat
dc.subjectIn-vivo
dc.subjectLinolenic Acid
dc.subjectCulinary Oils
dc.subjectDoxorubicin
dc.subjectBreast
dc.subjectCells
dc.subjectInduction
dc.titleNongenotoxic effects and a reduction of the DXR-induced genotoxic effects of Helianthus annuus Linne (sunflower) seeds revealed by micronucleus assays in mouse bone marrow
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución