Brasil | Artículos de revistas
dc.creatorMonteiro, MSDD
dc.creatorOzzetti, RA
dc.creatorVergnanini, AL
dc.creatorde Brito-Gitirana, L
dc.creatorVolpato, NM
dc.creatorde Freitas, ZMF
dc.creatorRicci, E
dc.creatordos Santos, EP
dc.date2012
dc.date2014-07-30T17:28:05Z
dc.date2015-11-26T16:45:06Z
dc.date2014-07-30T17:28:05Z
dc.date2015-11-26T16:45:06Z
dc.date.accessioned2018-03-28T23:30:39Z
dc.date.available2018-03-28T23:30:39Z
dc.identifierInternational Journal Of Nanomedicine. Dove Medical Press Ltd, v. 7, n. 3045, n. 3058, 2012.
dc.identifier1178-2013
dc.identifierWOS:000305633700001
dc.identifier10.2147/IJN.S28550
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65868
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65868
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274126
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionPurpose: Awareness of the harmful effects of ultraviolet radiation has led to the increasing use of sunscreens, thus, the development of safe and effective antisolar preparations is important. The inclusion of sunscreen molecules in different release systems, like liposomes (lipo) and cyclodextrins (CD) is therefore required. Methods: The in vivo sun protection factor (SPF), water resistance, and in vitro transdermal penetration test of octyl p-methoxycinnamate (OMC) in different dispersions, such as OMC encapsulated in liposomes (lipo/OMC), OMC encapsulated in beta-cyclodextrins (beta-CD/OMC), OMC encapsulated in both release systems (lipo/OMC and beta-CD/OMC), and an OMC-free formulation were determined. Results: Although the formulation containing only the lipo/OMC system revealed high value of in vivo SPF (11.0 +/- 1.3) and water resistance (SPF = 10.3 +/- 2.2), the formulation containing both release systems (lipo/OMC + beta-cyclodextrin/OMC) showed the best result in the in vivo SPF test (11.6 +/- 1.6). In the penetration test, the formulation containing the lipo/OMC system had better performance, since a high amount of OMC in the epidermis (18.04 +/- 1.17 mu g) and a low amount of OMC in the dermis (9.4 +/- 2.36 mu g) were observed. These results suggest that liposomes interact with the cells of the stratum corneum, promoting retention of OMC in this layer. Conclusion: According to our study, the lipo/OMC system is the most advantageous release system, due to its ability to both increase the amount of OMC in the epidermis and decrease the risk of percutaneous absorption.
dc.description7
dc.description3045
dc.description3058
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFarmacia Universitaria/UFRJ
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherDove Medical Press Ltd
dc.publisherAlbany
dc.publisherNova Zelândia
dc.relationInternational Journal Of Nanomedicine
dc.relationInt. J. Nanomed.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectoctyl p-methoxycinnamate
dc.subjectsunscreen
dc.subjectliposomes
dc.subjectbeta-cyclodextrin
dc.subjectpenetration
dc.subjectSunscreen Agent
dc.subjectSkin
dc.subjectAbsorption
dc.subjectPhotoprotection
dc.subjectPermeability
dc.subjectFormulations
dc.subjectAbsorbers
dc.subjectRelease
dc.subjectProduct
dc.subjectFilters
dc.titleEvaluation of octyl p-methoxycinnamate included in liposomes and cyclodextrins in anti-solar preparations: preparations, characterizations and in vitro penetration studies
dc.typeArtículos de revistas


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