Role of 17 beta-estradiol on type IV collagen fibers volumetric density in the basement membrane of bladder wall

dc.creatorde Fraga, R
dc.creatorDambros, M
dc.creatorMiyaoka, R
dc.creatorRiccetto, CLZ
dc.creatorPalma, PCR
dc.date2007
dc.dateOCT
dc.date2014-11-17T15:37:32Z
dc.date2015-11-26T16:44:24Z
dc.date2014-11-17T15:37:32Z
dc.date2015-11-26T16:44:24Z
dc.date.accessioned2018-03-28T23:29:44Z
dc.date.available2018-03-28T23:29:44Z
dc.identifierInternational Urogynecology Journal. Springer London Ltd, v. 18, n. 10, n. 1185, n. 1190, 2007.
dc.identifier0937-3462
dc.identifierWOS:000249871800010
dc.identifier10.1007/s00192-006-0294-4
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71202
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71202
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71202
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273912
dc.descriptionThe authors quantified the type IV collagen fibers volumetric density in the basement membrane of bladder wall of ovariectomized rats with and without estradiol replacement. This study was conducted on 40 Wistar rats (3 months old) randomly divided in 4 groups: group 1, remained intact (control); group 2, submitted to bilateral oophorectomy and daily replacement 4 weeks later of beta-estradiol for 12 weeks; group 3, sham operated and daily replacement 4 weeks later of sesame oil for 12 weeks; and group 4, submitted to bilateral oophorectomy and killed after 12 weeks. It was used in immunohistochemistry evaluation using type IV collagen polyclonal antibody to stain the fibers on paraffin rat bladder sections. The M-42 stereological grid system was used to analyze the fibers. Ovariectomy had an increase effect on the volumetric density of the type IV collagen fibers in the basement membrane of rat bladder wall Estradiol replacement in castrated animals demonstrated a significative difference in the stereological parameters when compared to the castrated group without hormonal replacement. Surgical castration performed on rats induced an increasing volumetric density of type IV collagen fibers in the basement membrane of rats bladder wall and the estradiol treatment had a significant effect in keeping a low volumetric density of type IV collagen fibers in the basement-membrane of rats bladder wall.
dc.description18
dc.description10
dc.description1185
dc.description1190
dc.languageen
dc.publisherSpringer London Ltd
dc.publisherArtington
dc.publisherInglaterra
dc.relationInternational Urogynecology Journal
dc.relationInt. Urogynecol. J.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectestradiol
dc.subjectbladder
dc.subjectrats
dc.subjectconnective tissue
dc.subjectUrinary-tract
dc.subjectReplacement
dc.subjectOvariectomy
dc.subjectPathology
dc.subjectRats
dc.titleRole of 17 beta-estradiol on type IV collagen fibers volumetric density in the basement membrane of bladder wall
dc.typeArtículos de revistas


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