Study of the vaginal tolerance to acidform, an acid-buffering, bioadhesive gel

dc.creatorAmaral, E
dc.creatorFaundes, A
dc.creatorZaneveld, L
dc.creatorWaller, D
dc.creatorGarg, S
dc.date1999
dc.dateDEC
dc.date2014-12-02T16:30:23Z
dc.date2015-11-26T16:44:16Z
dc.date2014-12-02T16:30:23Z
dc.date2015-11-26T16:44:16Z
dc.date.accessioned2018-03-28T23:29:34Z
dc.date.available2018-03-28T23:29:34Z
dc.identifierContraception. Elsevier Science Inc, v. 60, n. 6, n. 361, n. 366, 1999.
dc.identifier0010-7824
dc.identifierWOS:000085923100009
dc.identifier10.1016/S0010-7824(99)00102-X
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75355
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/75355
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75355
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273865
dc.descriptionVaginal tolerance tests were performed with a new potential microbicidal and spermicidal product, an acid-buffering vaginal gel (Acidform) without or with nonoxynol-9 (N-9). The potential advantages over other vaginal products include keeping a low pH, decrease of the irritating effect of N-9 on the cervix or vaginal mucosa associated with greater retention of the product after application, and decreasing "messiness" as compared to other vaginal products. Three groups of six women were admitted and randomly assigned to use Acidform with 0%, 2.5%, and 5% N-9. Colposcopic evaluation for vulvar, vaginal, and cervical signs of irritation was performed and photographs were taken, following a specific World Health Organization protocol, at time 0, and after 24 h and 6 days of application of the gel. No irritation or symptom was reported by users of Acidform without N-9. A generalized and intense erythema in cervix was observed in 10 of 12 Acidform/N-9 users and abrasion occurred in nine of them. Vulvar irritation was seen in seven of these 10 volunteers. N-9 concentration in the gel (2.5% or 5.0%) was not related to the findings. No ulcer, exulceration, or de-epithelialization was observed. Acidform without N-9 was well tolerated by volunteers, but it was unable to protect the cervix, vagina, and vulva from the N-9 effects. CONTRACEPTION 2000;60: 361-366 (C) 2000 Elsevier Science Inc. All rights reserved.
dc.description60
dc.description6
dc.description361
dc.description366
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationContraception
dc.relationContraception
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectvaginal tolerance
dc.subjectacid-buffering gel
dc.subjectspermicide
dc.subjectmicrobicide
dc.subjectsexually transmitted diseases
dc.subjectcontraception
dc.subjectHiv-infection
dc.subjectNonoxynol-9
dc.titleStudy of the vaginal tolerance to acidform, an acid-buffering, bioadhesive gel
dc.typeArtículos de revistas


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