MAPPING OF A CHROMOSOME-15 REGION INVOLVED IN LIMB-GIRDLE MUSCULAR-DYSTROPHY

dc.creatorFOUGEROUSSE, F
dc.creatorBROUX, O
dc.creatorRICHARD, I
dc.creatorALLAMAND, V
dc.creatorDESOUZA, AP
dc.creatorBOURG, N
dc.creatorBRENGUIER, L
dc.creatorDEVAUD, C
dc.creatorPASTURAUD, P
dc.creatorROUDAUT, C
dc.creatorCHIANNILKULCHAI, N
dc.creatorHILLAIRE, D
dc.creatorBUI, H
dc.creatorCHUMAKOV, I
dc.creatorWEISSENBACH, J
dc.creatorCHERIF, D
dc.creatorCOHEN, D
dc.creatorBECKMANN, JS
dc.date1994
dc.dateFEB
dc.date2014-07-30T13:39:45Z
dc.date2015-11-26T16:44:15Z
dc.date2014-07-30T13:39:45Z
dc.date2015-11-26T16:44:15Z
dc.date.accessioned2018-03-28T23:29:33Z
dc.date.available2018-03-28T23:29:33Z
dc.identifierHuman Molecular Genetics. Oxford Univ Press United Kingdom, v. 3, n. 2, n. 285, n. 293, 1994.
dc.identifier0964-6906
dc.identifierWOS:A1994MY58300011
dc.identifier10.1093/hmg/3.2.285
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53222
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/53222
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273862
dc.descriptionA gene responsible for an autosomal recessive form of limb girdle muscular dystrophy (LGMDP2, MIM number 253600) has been localized on chromosome 15. After genotyping additional markers of this chromosome, two were found to flank the disease locus within an interval that was assessed as 7 centiMorgans. The screening of the CEPH YAC libraries with the corresponding probes allowed the isolation of YACs which were used in fluorescence in situ hybridization to define the LGMD2 cytogenetic interval as 15q15.1-15q21.1. Four different approaches were pursued for the establishment of the physical map of this area which allowed the assembly of an uninterrupted YAC contig spanning an estimated 10-12 megabases, with an average STS resolution of 140 kb or for the 25 polymorphic microsatellites on this map, of 400 kb. Twelve genes and 25 genetic markers were positioned in this contig, which is constituted of a minimum of 10 clones.
dc.description3
dc.description2
dc.description285
dc.description293
dc.languageen
dc.publisherOxford Univ Press United Kingdom
dc.publisherOxford
dc.publisherInglaterra
dc.relationHuman Molecular Genetics
dc.relationHum. Mol. Genet.
dc.rightsfechado
dc.rightshttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.sourceWeb of Science
dc.subjectYeast Artificial Chromosomes
dc.subjectPolymerase Chain-reaction
dc.subjectHuman Genome
dc.subjectLinkage
dc.subjectGenes
dc.subjectPolymorphisms
dc.subjectLocalization
dc.subjectVariants
dc.subjectLibrary
dc.subjectKinase
dc.titleMAPPING OF A CHROMOSOME-15 REGION INVOLVED IN LIMB-GIRDLE MUSCULAR-DYSTROPHY
dc.typeArtículos de revistas


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