Severe obstructive disease: Similarities and differences between smoker and non-smoker patients with COPD and/or bronchiectasis

dc.creatorGoncalves, JR
dc.creatorPereira, MC
dc.creatorDe Cerqueira, EMFP
dc.creatorMagro, DO
dc.creatorMoreira, MM
dc.creatorPaschoal, IA
dc.date2013
dc.dateJAN-FEB
dc.date2014-07-31T14:36:58Z
dc.date2015-11-26T16:44:10Z
dc.date2014-07-31T14:36:58Z
dc.date2015-11-26T16:44:10Z
dc.date.accessioned2018-03-28T23:29:25Z
dc.date.available2018-03-28T23:29:25Z
dc.identifierRevista Portuguesa De Pneumologia. Elsevier Doyma Sl, v. 19, n. 1, n. 13, n. 18, 2013.
dc.identifier0873-2159
dc.identifierWOS:000313860700003
dc.identifier10.1016/j.rppneu.2012.05.003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75695
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75695
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273831
dc.descriptionIntroduction: Poorly reversible airflow obstruction may or may not be related to smoking. Objectives: To describe patients with severe obstructive lung disease including etiology, imaging, functional aspects, systemic manifestations, and the pattern of bronchodilator response. Methods: Sixty-eight patients (age 55.9 +/- 13.7 years, FEV1 [forced expiratory volume in one second] 31.9 +/- 10.2% predicted) underwent spirometry, evaluation of body mass composition, 6-minute walk test, X-ray, thorax high-resolution CT scanning, and clinical evaluation. Results: Of 68 patients enrolled, 37 had chronic obstructive pulmonary disease (COPD) and 31, extensive bronchiectasis. Among COPD patients the CT scans showed emphysema in 78.4%, and bronchiectasis in 48.6%. There were no significant differences between smokers and nonsmokers, except for vital capacity, significantly smaller in non-smokers (p<0.001). We found 29 and 20 volume responders (VR) according to Pare et al. (FEV1/FVC > 1 = flow responder or <1 =VR) and ATS/ERS criteria, respectively. According to Pare et al. criteria, there were 18 patients with FEV1 <30% predicted among 29 VR, and 12 with FEV1 <30% predicted among 39 without volume response (p=0.0101). Conclusions: In patients with severe obstruction, smoking does not appear to be relevant in determining functional or systemic differences, and Pare et al. criteria can detect more VR. Bronchiectasis is a common finding in severe COPD. (C) 2012 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved.
dc.description19
dc.description1
dc.description13
dc.description18
dc.languageen
dc.publisherElsevier Doyma Sl
dc.publisherBarcelona
dc.publisherEspanha
dc.relationRevista Portuguesa De Pneumologia
dc.relationRev. Port. Pneumol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAirway obstruction
dc.subjectRespiratory function tests
dc.subjectBronchitis
dc.subjectBronchiectasis
dc.subjectBronchodilator tests
dc.subjectComputed tomography of the thorax
dc.subjectAir-flow Obstruction
dc.subjectNutrition-examination-survey
dc.subjectPulmonary-disease
dc.subjectLung-function
dc.subjectNational-health
dc.subjectNatural-history
dc.subjectFunction Tests
dc.subjectUnited-states
dc.subjectBronchodilators
dc.subjectDyspnea
dc.titleSevere obstructive disease: Similarities and differences between smoker and non-smoker patients with COPD and/or bronchiectasis
dc.typeArtículos de revistas


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