Serum leptin level in hypertensive middle-aged obese women

dc.creatorde Moraes, C
dc.creatorRomero, CEM
dc.creatorFarias-Silva, E
dc.creatorZanesco, A
dc.date2005
dc.dateJUL-AUG
dc.date2014-07-31T14:35:29Z
dc.date2015-11-26T16:44:03Z
dc.date2014-07-31T14:35:29Z
dc.date2015-11-26T16:44:03Z
dc.date.accessioned2018-03-28T23:29:16Z
dc.date.available2018-03-28T23:29:16Z
dc.identifierEndocrinologist. Lippincott Williams & Wilkins, v. 15, n. 4, n. 219, n. 221, 2005.
dc.identifier1051-2144
dc.identifierWOS:000230875400007
dc.identifier10.1097/01.ten.0000170963.12130.70
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75671
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75671
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273791
dc.descriptionThe mechanism by which adiposity can raise blood pressure is not fully understood. Leptin has been suggested as a possible cause of the arterial hypertension in obese subjects because leptin induces an increase in sympathetic activity. The aim of the present study is to evaluate serum leptin level, blood pressure, lipid profile, blood glucose, and insulin in obese women. Leptin, total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were measured. Serum leptin was markedly higher in hypertensive obese women (92.3 +/- 22 ng/mL, n = 7) as compared with normotensive obese women (37.7 +/- 11 ng/mL, n = 7). Similarly, total cholesterol and LDL cholesterol were significantly elevated in the hypertensive group. No changes were observed in triglycerides and high-density lipoprotein cholesterol concentration between the 2 groups. There were no significant differences in plasma insulin concentration or blood glucose in both groups. In conclusion, our findings suggest a link among dyslipidemia, leptin level, and hypertension that might be relevant to the development of cardiovascular disease in obese subjects.
dc.description15
dc.description4
dc.description219
dc.description221
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationEndocrinologist
dc.relationEndocrinologist
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectobesity
dc.subjectleptin
dc.subjectblood pressure
dc.subjectwomen
dc.subjectSympathetic-nerve Activity
dc.subjectPlasma Leptin
dc.subjectCholesterol
dc.subjectMechanisms
dc.subjectSecretion
dc.subjectHumans
dc.titleSerum leptin level in hypertensive middle-aged obese women
dc.typeArtículos de revistas


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