| dc.creator | da Silva, MA | |
| dc.creator | Rafacho, BPM | |
| dc.creator | Hiruma-Lima, CA | |
| dc.creator | da Rocha, LRM | |
| dc.creator | dos Santos, LC | |
| dc.creator | Sannomiya, M | |
| dc.creator | Souza-Brito, ARM | |
| dc.creator | Vilegas, W | |
| dc.date | 2005 | |
| dc.date | AUG | |
| dc.date | 2014-11-17T13:22:44Z | |
| dc.date | 2015-11-26T16:43:24Z | |
| dc.date | 2014-11-17T13:22:44Z | |
| dc.date | 2015-11-26T16:43:24Z | |
| dc.date.accessioned | 2018-03-28T23:28:25Z | |
| dc.date.available | 2018-03-28T23:28:25Z | |
| dc.identifier | Chemical & Pharmaceutical Bulletin. Pharmaceutical Soc Japan, v. 53, n. 8, n. 881, n. 885, 2005. | |
| dc.identifier | 0009-2363 | |
| dc.identifier | WOS:000231320700002 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65924 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/65924 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/65924 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1273576 | |
| dc.description | Strychnos pseudoquina Sr. HiL.. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. | |
| dc.description | 53 | |
| dc.description | 8 | |
| dc.description | 881 | |
| dc.description | 885 | |
| dc.language | en | |
| dc.publisher | Pharmaceutical Soc Japan | |
| dc.publisher | Tokyo | |
| dc.publisher | Japão | |
| dc.relation | Chemical & Pharmaceutical Bulletin | |
| dc.relation | Chem. Pharm. Bull. | |
| dc.rights | aberto | |
| dc.source | Web of Science | |
| dc.subject | Strychnos pseudoquina | |
| dc.subject | antiulcer activity | |
| dc.subject | toxic activity | |
| dc.subject | alkaloid | |
| dc.subject | Alkaloids | |
| dc.subject | Spectroscopy | |
| dc.subject | Lesions | |
| dc.subject | Rats | |
| dc.title | Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice | |
| dc.type | Artículos de revistas | |
