Fibrates and fish oil, but not corn oil, up-regulate the expression of the cholesteryl ester transfer protein (CETP) gene

dc.creatorRaposo, HF
dc.creatorPatricio, PR
dc.creatorSimoes, MC
dc.creatorOliveira, HCF
dc.date2014
dc.dateJUN
dc.date2014-07-30T17:34:53Z
dc.date2015-11-26T16:43:06Z
dc.date2014-07-30T17:34:53Z
dc.date2015-11-26T16:43:06Z
dc.date.accessioned2018-03-28T23:27:59Z
dc.date.available2018-03-28T23:27:59Z
dc.identifierJournal Of Nutritional Biochemistry. Elsevier Science Inc, v. 25, n. 6, n. 669, n. 674, 2014.
dc.identifier0955-2863
dc.identifier1873-4847
dc.identifierWOS:000336355600011
dc.identifier10.1016/j.jnurbio.2014.02.008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66912
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66912
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273488
dc.descriptionCholesteryl ester transfer protein (CETP) is a plasma protein that reduces high density lipoprotein (HDL)-cholesterol (chol) levels and may increase atherosclerosis risk. n-3 and n-6 polyunsaturated fatty acids (PUFAs) are natural ligands, and fibrates are synthetic ligands for peroxisome proliferator activated receptor-alpha (PPAR alpha), a transcription factor that modulates lipid metabolism. In this study, we investigated the effects of PUFA oils and fibrates on CETP expression. Hypertriglyceridemic CETP transgenic mice were treated with gemfibrozil, fenofibrate, bezafibrate or vehicle (control), and normolipidemic CETP transgenic mice were treated with fenofibrate or with fish oil (FO; n-3 PUFA rich), corn oil (CO, n-6 PUFA rich) or saline. Compared with the control treatment, only fenofibrate significantly diminished triglyceridemia (50%), whereas all fibrates decreased the HDL-chol level. Elevation of the CETP liver mRNA levels and plasma activity was observed in the fenofibrate (53%) and gemfibrozil (75%) groups. Compared with saline, FO reduced the plasma levels of nonesterified fatty acid (26%), total chol (15%) and HDL-chol (20%). Neither of the oil treatments affected the plasma triglyceride levels. Compared with saline, FO increased the plasma adiponectin level and reduced plasma leptin levels, whereas CO increased the leptin levels. FO, but not CO, significantly increased the plasma CETP mass (90%) and activity (23%) as well as increased the liver level of CETP mRNA (28%). In conclusion, fibrates and FO, but not CO, up-regulated CETP expression at both the mRNA and protein levels. We propose that these effects are mediated by the activation of PPARa, which acts on a putative PPAR response element in the CETP gene. (C) 2014 Elsevier Inc. All rights reserved.
dc.description25
dc.description6
dc.description669
dc.description674
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationJournal Of Nutritional Biochemistry
dc.relationJ. Nutr. Biochem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectCETP expression
dc.subjectFish oil
dc.subjectOmega-3 polyunsaturated fatty acids
dc.subjectFibrates
dc.subjectHigh-density-lipoprotein
dc.subjectProliferator-activated-receptor
dc.subjectLipid Transfer Proteins
dc.subjectHigh-fat Diet
dc.subjectTransgenic Mice
dc.subjectCardiovascular-disease
dc.subjectIib Hyperlipoproteinemia
dc.subjectBezafibrate Therapy
dc.subjectLdl Receptor
dc.subjectA-i
dc.titleFibrates and fish oil, but not corn oil, up-regulate the expression of the cholesteryl ester transfer protein (CETP) gene
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución