Development and Evaluation of Praziquantel Solid Dispersions in Sodium Starch Glycolate

dc.creatorChaud, MV
dc.creatorLima, AC
dc.creatorVila, MM
dc.creatorPaganelli, MO
dc.creatorPaula, FC
dc.creatorPedreiro, LN
dc.creatorGremiao, MP
dc.date2013
dc.dateAPR
dc.date2014-07-30T14:39:49Z
dc.date2015-11-26T16:43:02Z
dc.date2014-07-30T14:39:49Z
dc.date2015-11-26T16:43:02Z
dc.date.accessioned2018-03-28T23:27:54Z
dc.date.available2018-03-28T23:27:54Z
dc.identifierTropical Journal Of Pharmaceutical Research. Pharmacotherapy Group, v. 12, n. 2, n. 163, n. 168, 2013.
dc.identifier1596-5996
dc.identifierWOS:000318672800005
dc.identifier10.4314/tjpr.v12i2.5
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61524
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61524
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273466
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionPurpose: To develop and characterize solid dispersions of praziquantel (PZQ) with sodium starch glycolate (SSG) for enhanced drug solubility. Methods: PZQ solid dispersion (SD) was prepared using co-precipitation method by solvent evaporation. The ratios of PZQ to SSG were 2:1, 1:1, 1:2, 1:3 (w/w). PZQ solubility was evaluated in purified water, and PZQ dissolution test was carried out in 0.1N HCl. Structural characterization of the dispersions was accomplished by x-ray diffraction (XRD) and infrared spectroscopy (FTIR) while the external morphology of the SDs, SSG and PZQ were studied by scanning electron microscopy (SEM). Mucoadhesion properties of the SD (1:3) and SSG, on mucin disks were examined using texture profile analysis. Results: The highest solubility was obtained with 1:3 solid dispersion, with PZQ solubility of 97.31 %, which is 3.65-fold greater than the solubility of pure PZQ and physical misture (PM, 1:3). XRD results indicate a reduction in PZQ crystallinity while infrared spectra showed that the functional groups of PZQ and SSG were preserved. SEM showed that the physical structure of PZQ was modified from crystalline to amorphous. The amount of PZQ in PM and SD (1:3) that dissolved in 60 min was 70 and 88 %, respectively, and these values increased to 76 and 96 %, respectively. The solid dispersion reduced the mucoadhesive property of the glycolate. Conclusion: Solid dispersion formulation using SSG is a good alternative approach for increasing the dissolution rate of PZQ.
dc.description12
dc.description2
dc.description163
dc.description168
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionSorocaba University
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherPharmacotherapy Group
dc.publisherBenin City
dc.publisherNigéria
dc.relationTropical Journal Of Pharmaceutical Research
dc.relationTrop. J. Pharm. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectPraziquantel
dc.subjectDrug bioavailability
dc.subjectSchistosomiasis
dc.subjectSolid dispersion
dc.subjectCo-precipitation
dc.subjectSodium starch glycolate
dc.subjectIntestinal-absorption
dc.subjectDissolution
dc.subjectSolubility
dc.subjectEnhancement
dc.titleDevelopment and Evaluation of Praziquantel Solid Dispersions in Sodium Starch Glycolate
dc.typeArtículos de revistas


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