Photodynamic Inactivation of Yeast and Bacteria by Extracts of Alternanthera brasiliana

dc.creatorAndreazza, NL
dc.creatorde Loureno, CC
dc.creatorSiqueira, CAT
dc.creatorSawaya, ACHF
dc.creatorLapinski, TF
dc.creatorGasparetto, A
dc.creatorKhouri, S
dc.creatorZamuner, SR
dc.creatorMunin, E
dc.creatorSalvador, MJ
dc.date2013
dc.dateAUG
dc.date2014-07-30T14:31:44Z
dc.date2015-11-26T16:42:55Z
dc.date2014-07-30T14:31:44Z
dc.date2015-11-26T16:42:55Z
dc.date.accessioned2018-03-28T23:27:40Z
dc.date.available2018-03-28T23:27:40Z
dc.identifierCurrent Drug Targets. Bentham Science Publ Ltd, v. 14, n. 9, n. 1015, n. 1022, 2013.
dc.identifier1389-4501
dc.identifierWOS:000321338500010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59601
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59601
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273425
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThis study was undertaken to evaluate the effect of Alternathera brasiliana (Amaranthaceae) extracts as photosensitizing agents in photodynamic antimicrobial therapies (PACT) against Staphylococcus aureus, Staphylococcus epidermidis and Candida dubliniensis. The crude hexane and ethanol extracts were obtained from A. brasiliana whole plant and showed absortion from 650 to 700nm. Also, singlet molecular oxygen (O-1(2)) production (type II photosensitization reaction) was examined, and the results show that 1,3-diphenylisobenzofuran photodegradation was greatly enhanced in the presence of the A. brasiliana extracts. One plate in each assay was irradiated while the other was not irradiated, the number of colony-forming units per milliliter (CFU/mL) was obtained, and data analyzed by the Tukey test. The chemical composition of the extracts was determined by chromatographic and spectrometric techniques; steroids, triterpenes, and flavonoids were identified. Laser irradiation alone at 685nm using diode laser, output power of 35mW, and energy of 28 J/cm(2), or non-irradiated crude extracts in sub-inhibitory concentration did not reduce the number of CFU/mL significantly, whereas irradiated hexane and ethanol extracts, in sub-inhibitory concentrations, inhibited the growth of these microorganisms. The photoactivation of hexane and ethanol extracts of A. brasiliana, in sub-inhibitory concentrations, using red laser radiation at 685nm had an antimicrobial effect.
dc.description14
dc.description9
dc.description1015
dc.description1022
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAEPEX-UNICAMP
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherBentham Science Publ Ltd
dc.publisherSharjah
dc.publisherEmirados Árabes Unidos
dc.relationCurrent Drug Targets
dc.relationCurr. Drug Targets
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectAlternanthera brasiliana
dc.subjectantimicrobial therapy
dc.subjectPACT
dc.subjectPDT
dc.subjectphotosensitizer
dc.subjectAntimicrobial Chemotherapy Pact
dc.subjectCoagulase-negative Staphylococci
dc.subjectIn-vitro
dc.subjectCandida-albicans
dc.subjectCallus-culture
dc.subjectTherapy
dc.subjectBiofilms
dc.subjectPhotosensitizers
dc.subjectMicroorganisms
dc.subjectAmaranthaceae
dc.titlePhotodynamic Inactivation of Yeast and Bacteria by Extracts of Alternanthera brasiliana
dc.typeArtículos de revistas


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