Ixodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases

dc.creatorFogaca, AC
dc.creatorAlmeida, IC
dc.creatorEberlin, MN
dc.creatorTanaka, AS
dc.creatorBulet, P
dc.creatorDaffre, S
dc.date2006
dc.dateAPR
dc.date2014-11-17T11:55:03Z
dc.date2015-11-26T16:42:45Z
dc.date2014-11-17T11:55:03Z
dc.date2015-11-26T16:42:45Z
dc.date.accessioned2018-03-28T23:27:27Z
dc.date.available2018-03-28T23:27:27Z
dc.identifierPeptides. Elsevier Science Inc, v. 27, n. 4, n. 667, n. 674, 2006.
dc.identifier0196-9781
dc.identifierWOS:000237047000009
dc.identifier10.1016/j.peptides.2005.07.013
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60888
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60888
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60888
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273369
dc.descriptionThe presence of an effective immune response in the hemocoel of arthropods is essential for survival as it prevents the invasion of pathogens throughout the animal body. Antimicrobial peptides (AMPs) play an important role in this response by rapidly killing invading microorganisms. In this study, a novel cysteine-rich AMP has been isolated and characterized from the hemocytes of the cattle tick, Boophilus microplus. In addition to growth inhibition of Escherichia coli and Micrococcus luteus, the newly described AMP, designated ixodidin (derived from the Family Ixodidae), was found to exert proteolytic inhibitory activity against two exogenous serine proteinases, elastase and chymotrypsin. This is the first report of a molecule of an arachnid that has been shown to inhibit bacterial growth and proteinase activity. (c) 2005 Elsevier Inc. All rights reserved.
dc.description27
dc.description4
dc.description667
dc.description674
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationPeptides
dc.relationPeptides
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectantimicrobial peptide
dc.subjectserine proteinase inhibitor
dc.subjectimmune system
dc.subjecthemocyte
dc.subjecttick
dc.subjectSpider Acanthoscurria-gomesiana
dc.subjectHorseshoe-crab
dc.subjectCellular-localization
dc.subjectChymotrypsin Elastase
dc.subjectInsect Defensin
dc.subjectInnate Immunity
dc.subjectCdna Cloning
dc.subjectDrosophila
dc.subjectExpression
dc.subjectBinding
dc.titleIxodidin, a novel antimicrobial peptide from the hemocytes of the cattle tick Boophilus microplus with inhibitory activity against serine proteinases
dc.typeArtículos de revistas


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