Baroreceptor reflex and integrative stress responses in chronic fatigue syndrome

dc.creatorPeckerman, A
dc.creatorLaManca, JJ
dc.creatorQureishi, B
dc.creatorDahl, KA
dc.creatorGolfetti, R
dc.creatorYamamoto, Y
dc.creatorNatelson, BH
dc.date2003
dc.dateSEP-OCT
dc.date2014-11-17T12:01:12Z
dc.date2015-11-26T16:42:45Z
dc.date2014-11-17T12:01:12Z
dc.date2015-11-26T16:42:45Z
dc.date.accessioned2018-03-28T23:27:27Z
dc.date.available2018-03-28T23:27:27Z
dc.identifierPsychosomatic Medicine. Lippincott Williams & Wilkins, v. 65, n. 5, n. 889, n. 895, 2003.
dc.identifier0033-3174
dc.identifierWOS:000185670300026
dc.identifier10.1097/01.PSY.0000079408.62277.3D
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55315
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55315
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55315
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273368
dc.descriptionObjective: Altered cardiovascular responses to mental and postural stressors have been reported in chronic fatigue syndrome (CFS). This study examined whether those findings may involve changes in baroreceptor reflex functioning. Methods: Chronotropic baroreceptor reflex (by sequential analysis) and cardiovascular stress responses were recorded during postural (5-minute of active standing) and cognitive (speech task) stress testing in patients with CFS grouped into cases with severe (N = 21) or less severe (N = 22) illness, and in 29 matched control subjects. Results: Patients with CFS had a greater decline in baroreceptor reflex sensitivity (BRS) during standing, although only those with severe CFS were significantly different from the controls. Systolic blood pressure declined during standing in the control group but was maintained in the CFS patients. In contrast, the patients with less severe CFS had blunted increases in blood pressure during the speech task, which could not, however, be explained by inadequate inhibition of the baroreceptor reflex, with all groups showing an appropriate reduction in BRS during the task. Conclusions: These results indicate that in CFS, deficiencies in orthostatic regulation, but not in centrally mediated stress responses, may involve the baroreceptor reflex. This study also suggests that classifying patients with CFS on illness severity may discriminate between patients with abnormalities in peripheral vs. central mechanisms of cardiovascular stress responses.
dc.description65
dc.description5
dc.description889
dc.description895
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationPsychosomatic Medicine
dc.relationPsychosom. Med.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectchronic fatigue syndrome
dc.subjectbaroreceptor reflex
dc.subjectorthostasis
dc.subjectcardiovascular reactivity
dc.subjectBlood-pressure
dc.subjectBaroreflex Sensitivity
dc.subjectOrthostatic Tolerance
dc.subjectGeneral-population
dc.subjectMultiple-sclerosis
dc.subjectPlasma-volume
dc.subjectMental Stress
dc.subjectSystem
dc.subjectHypertension
dc.subjectReactivity
dc.titleBaroreceptor reflex and integrative stress responses in chronic fatigue syndrome
dc.typeArtículos de revistas


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