Bacteriocin susceptibility of Gardnerella vaginalis and its relationship to biotype, genotype, and metronidazole susceptibility

dc.creatorSimoes, JA
dc.creatorAroutcheva, A
dc.creatorHeimler, I
dc.creatorShott, S
dc.creatorFaro, S
dc.date2001
dc.dateNOV
dc.date2014-11-17T10:09:18Z
dc.date2015-11-26T16:42:13Z
dc.date2014-11-17T10:09:18Z
dc.date2015-11-26T16:42:13Z
dc.date.accessioned2018-03-28T23:26:40Z
dc.date.available2018-03-28T23:26:40Z
dc.identifierAmerican Journal Of Obstetrics And Gynecology. Mosby, Inc, v. 185, n. 5, n. 1186, n. 1190, 2001.
dc.identifier0002-9378
dc.identifierWOS:000172396100033
dc.identifier10.1067/mob.2001.118144
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55281
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55281
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55281
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273187
dc.descriptionOBJECTIVE: Our purpose was to Investigate the bacteriocin susceptibility of Gardnerella vaginalis and its relationship to biotype, genotype, and resistance to metronidazole. STUDY DESIGN: Bacteriocin susceptibility of 36 G vaginalis clinical Isolates was tested against a vaginal strain of Lactobacillus acidophilus by a growth-inhibition method. The relationship to biotype, genotype, and resistance to metronidazole were analyzed by the chi (2) test and Fisher exact test. RESULTS: Eight G vaginalis strains (22%) were bacteriocin-resistant. Biotypes 5 and 7 were found to be the most frequent among these resistant strains. Eight (42%) of the 19 isolates classified as biotype 5, 6, or 7 were bacteriocin-resistant compared with none of the isolates that were classified as other biotypes (P < .01). Biotype 5 was found in higher prevalence among the isolates resistant to bacteriocin (62%) than among the susceptible isolates (14%) (P=.01). Genotype B was found more frequently among the bacteriocin-resistant strains, but this finding was not statistically significant (P=.71). Seven (88%) bacteriocin-resistant strains were also resistant to metronidazole. CONCLUSION: An association between biotype and an increased resistance to bacteriocin was found. The ability of G vaginalis to resist the antibacterial activity of Lactobacillus bacteriocin may be a pivotal factor in understanding bacterial vaginosis.
dc.description185
dc.description5
dc.description1186
dc.description1190
dc.languageen
dc.publisherMosby, Inc
dc.publisherSt Louis
dc.publisherEUA
dc.relationAmerican Journal Of Obstetrics And Gynecology
dc.relationAm. J. Obstet. Gynecol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectGardnerella vaginalis
dc.subjectbacteriocin
dc.subjectbiotype
dc.subjectgenotype
dc.subjectmetronidazole susceptibility
dc.subjectbacterial vaginosis
dc.subjectLactobacilli
dc.subjectVaginosis
dc.titleBacteriocin susceptibility of Gardnerella vaginalis and its relationship to biotype, genotype, and metronidazole susceptibility
dc.typeArtículos de revistas


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