Biotransformation of Phenylacetonitrile to 2-Hydroxyphenylacetic Acid by Marine Fungi

dc.creatorde Oliveira, JR
dc.creatorMizuno, CM
dc.creatorSeleghim, MHR
dc.creatorJavaroti, DCD
dc.creatorRezende, MOO
dc.creatorLandgraf, MD
dc.creatorSette, LD
dc.creatorPorto, ALM
dc.date2013
dc.dateFEB
dc.date2014-07-30T13:52:21Z
dc.date2015-11-26T16:42:08Z
dc.date2014-07-30T13:52:21Z
dc.date2015-11-26T16:42:08Z
dc.date.accessioned2018-03-28T23:26:34Z
dc.date.available2018-03-28T23:26:34Z
dc.identifierMarine Biotechnology. Springer, v. 15, n. 1, n. 97, n. 103, 2013.
dc.identifier1436-2228
dc.identifierWOS:000312740300010
dc.identifier10.1007/s10126-012-9464-1
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55706
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55706
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1273164
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionMarine fungi belonging to the genera Aspergillus, Penicillium, Cladosporium, and Bionectria catalyzed the biotransformation of phenylacetonitrile to 2-hydroxyphenylacetic acid. Eight marine fungi, selected and cultured with phenylacetonitrile in liquid mineral medium, catalyzed it quantitative biotransformation to 2-hydroxyphenylacetic acid. In this study, the nitrile group was firstly hydrolysed, and then, the aromatic ring was hydroxylated, producing 2-hydroxyphenylacetic acid with 51 % yield isolated. In addition, the 4-fluorophenylacetonitrile was exclusively biotransformed to 4-fluorophenylacetic acid by Aspergillus sydowii Ce19 (yield = 51 %). The enzymatic biotransformation of nitriles is not trivial, and here, we describe an efficient method for production of phenylacetic acids in mild conditions.
dc.description15
dc.description1
dc.description97
dc.description103
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2008/56371-9]
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationMarine Biotechnology
dc.relationMar. Biotechnol.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectNitrile
dc.subjectMarine fungi
dc.subjectBiotransformation
dc.subjectHydroxylation
dc.subject4-Fluorophenylacetonitrile
dc.subjectAcidotolerant Black Yeast
dc.subjectExophiala-oligosperma R1
dc.subjectSubstrate-specificity
dc.subjectAspergillus Sydowii
dc.subjectFilamentous Fungi
dc.subjectNitrilase
dc.subjectHydrolysis
dc.subjectPurification
dc.subjectEnzymes
dc.subjectNiger
dc.titleBiotransformation of Phenylacetonitrile to 2-Hydroxyphenylacetic Acid by Marine Fungi
dc.typeArtículos de revistas


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