Flavonoids of Lonchocarpus montanus AMG Azevedo and biological activity

dc.creatorMagalhaes, AF
dc.creatorTozzi, AMGA
dc.creatorMagalhaes, EG
dc.creatorSannomiya, M
dc.creatorSoriano, MDPC
dc.creatorPerez, MAF
dc.date2007
dc.dateSEP
dc.date2014-11-17T08:34:59Z
dc.date2015-11-26T16:41:35Z
dc.date2014-11-17T08:34:59Z
dc.date2015-11-26T16:41:35Z
dc.date.accessioned2018-03-28T23:25:50Z
dc.date.available2018-03-28T23:25:50Z
dc.identifierAnais Da Academia Brasileira De Ciencias. Acad Brasileira De Ciencias, v. 79, n. 3, n. 351, n. 367, 2007.
dc.identifier0001-3765
dc.identifierWOS:000249384000001
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79977
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/79977
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79977
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272974
dc.descriptionThe analysis of root extracts from Lonchocarpus montanus A.M.G. Azevedo resulted in the isolation of twenty three compounds chiefly flavonoids of which five (four flavonoids and one benzophenone) are described for the first time. The molecular structures of the new compounds (1-5) were determined through spectral analysis (UV, IR, MS and NMR) as being: 2'-hydroxy-8-(alpha,alpha-dimethylallyl)-2',2'-dimethyl-pyrano-(5',6':3',4')-dibenzoylmethane(1), 2'-methoxy-8-(alpha,alpha-dimethylallyl)-2', 2'- dimethylpyrano(5', 6': 3', 4')-dibenzoylmethane (2), 4'-methoxy-2', 2'- dimethylpyrano-(5', 6':8,7)-flavone (3), 2'-(1-hydroxy-1-methylethyl)- furano-(4',5':8,7)- flavone (4) and [2'-methoxy-furano-(4',5':3',4')- phenyl]phenylmethanone (5). Additionally, fifteen fatty acids were detected through GC- MS analysis of the corresponding methyl esters [(CH3)(2)CH(CH2)(8)COOH and CH3(CH2)(n)COOH (n = 6, 12- 24)]. Quantitative RP- HPLC showed that the most abundant flavonoids in the petroleum ether and dichloromethane extracts were pongamol (19%) and lanceolatine B (8.0%), respectively. In the bioautography assay, the extracts, pongamol ( 9), lanceolatine B (10), isolonchocarpin (14), derriobtusone A (17) and medicarpine ( 18) were active against Staphilococus aureus whereas 9 also against Bacillus subtilis and Cladosporium cladosporioides. Compound 1, 2', 2'-dimethylpyrano-(5', 6':8,7)- flavone (11) and furano-(12', 13':7,8)-4'- methoxy flavone (12) were active against Fusarium oxysporium whereas 11 also against Rhizopus orizae. The extracts, compounds 9, 10, 17 and (E)-7- O- methoxypongamol (23) displayed high toxicity in the brine shrimp lethality assay.
dc.description79
dc.description3
dc.description351
dc.description367
dc.languageen
dc.publisherAcad Brasileira De Ciencias
dc.publisherRio Janeiro
dc.publisherBrasil
dc.relationAnais Da Academia Brasileira De Ciencias
dc.relationAn. Acad. Bras. Cienc.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectLonchocarpus montanus AMG Azevedo
dc.subjectleguminosae
dc.subjectdibenzoylmethanes
dc.subjectflavonoids
dc.subjectflavones
dc.subjectbenzophenone
dc.subjectbioautography
dc.subjectArtemia salina lethality
dc.subjectTephrosia-purpurea
dc.subjectPrenylated Flavonoids
dc.subjectPongamia-glabra
dc.subjectDibenzoylmethane Derivatives
dc.subjectPhenolic Constituents
dc.subjectPlant Flavonoids
dc.subjectHeart-disease
dc.subjectRoot Bark
dc.subjectExtracts
dc.subjectCancer
dc.titleFlavonoids of Lonchocarpus montanus AMG Azevedo and biological activity
dc.typeArtículos de revistas


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