Evaluation of the relationship between interleukin-1 gene cluster polymorphisms and early implant failure in non-smoking patients

dc.creatorCampos, MIG
dc.creatorSantos, MCLG
dc.creatorTrevilatto, PC
dc.creatorScarel-Caminaga, RM
dc.creatorBezerra, FJB
dc.creatorLine, SRP
dc.date2005
dc.dateAPR
dc.date2014-11-17T07:55:32Z
dc.date2015-11-26T16:41:18Z
dc.date2014-11-17T07:55:32Z
dc.date2015-11-26T16:41:18Z
dc.date.accessioned2018-03-28T23:25:29Z
dc.date.available2018-03-28T23:25:29Z
dc.identifierClinical Oral Implants Research. Blackwell Munksgaard, v. 16, n. 2, n. 194, n. 201, 2005.
dc.identifier0905-7161
dc.identifierWOS:000227774600009
dc.identifier10.1111/j.1600-0501.2004.01091.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66007
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/66007
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66007
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272890
dc.descriptionObjective: The aim of the present study was to investigate the relationship between specific polymorphisms of the interleukin-1 gene cluster and the early failure of osseointegrated implants. Material and methods: The subject population was composed by a test group comprising 28 non-smoking patients (mean age 52.7) that had suffered one or more early implant failures and by a control group consisting of 34 individuals (mean age 43.3) with one or more healthy implants. Genomic DNA from buccal mucosa was amplified by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP) and submitted to polyacrylamide gel electrophoresis to distinguish the alleles of the interleukin-1A (-889), interleukin-1B (+3953), interleukin-1B (-511) and interleukin-RN (intron 2) gene polymorphisms. Differences in the allele and genotype frequencies between control and test groups were assessed by chi(2) test or by Monte Carlo simulations (P < 0.05). Haplotype frequencies, linkage disequilibrium and Hardy-Weinberg equilibrium were also estimated. Results: No statistically significant differences were found in the genotype distribution or allelic frequencies of the polymorphisms. No differences were observed between control and test groups when different interleukin-1 gene cluster haplotypes were compared. Nevertheless, the interleukin-1A (-889) and interleukin-1B (+3953) polymorphic sites were in strong linkage disequilibrium (P=0.00014 for control group and P=0.0238 for the test group). Conclusion: This study suggests that polymorphisms in the interleukin-1 gene cluster are not associated with early implant failure in a non-smoking Brazilian population.
dc.description16
dc.description2
dc.description194
dc.description201
dc.languageen
dc.publisherBlackwell Munksgaard
dc.publisherCopenhagen
dc.publisherDinamarca
dc.relationClinical Oral Implants Research
dc.relationClin. Oral Implant. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectinterleukin-1 gene polymorphism
dc.subjectimplant failure
dc.subjectosseointegration
dc.subjectTumor-necrosis-factor
dc.subjectOsseointegrated Oral Implants
dc.subjectGingival Crevicular Fluid
dc.subjectEarly-onset Periodontitis
dc.subjectReceptor Antagonist
dc.subjectRheumatoid-arthritis
dc.subjectIl-1-beta Genes
dc.subjectBone-resorption
dc.subjectDental Implants
dc.subjectPlasma-levels
dc.titleEvaluation of the relationship between interleukin-1 gene cluster polymorphisms and early implant failure in non-smoking patients
dc.typeArtículos de revistas


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