Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: Interaction with nitric oxide

dc.creatorTeixeira, CE
dc.creatorPriviero, FBM
dc.creatorClaudino, MA
dc.creatorBaracat, JS
dc.creatorDe Nucci, G
dc.creatorWebb, RC
dc.creatorAntunes, E
dc.date2006
dc.date41275
dc.date2014-11-17T07:36:35Z
dc.date2015-11-26T16:41:14Z
dc.date2014-11-17T07:36:35Z
dc.date2015-11-26T16:41:14Z
dc.date.accessioned2018-03-28T23:25:24Z
dc.date.available2018-03-28T23:25:24Z
dc.identifierEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 530, n. 41671, n. 157, n. 165, 2006.
dc.identifier0014-2999
dc.identifierWOS:000234704700022
dc.identifier10.1016/j.ejphar.2005.11.015
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79890
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/79890
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79890
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272867
dc.descriptionThe compound BAY 41-2272 stimulates the soluble guanylyl cyclase in a nitric oxide (NO)-independent manner. We have investigated the potency and efficacy of BAY 41-2272 in the rat anococcygeus muscle, as well as the effects of BAY 41-2272 on NO-mediated anococcygeus relaxations. BAY 41-2272 (0.01-10 mu M) potently relaxed precontracted anococcygeus muscle strips, with a pEC(50) value of 6.44 +/- 0.03 and maximum response of 100 +/- 2%. The soluble guanylyl cyclase inhibitor H-1-[1,2,4]-oxidiazolo[4,3-a] quinoxalin-1-one (ODQ, 1 mu M) and the NO inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME, 100 mu M) caused significant rightward shifts in the concentration-response curves to BAY 41-2272. The phosphodiesterase type-5 inhibitor tadalafil (0.1 mu M) markedly enhanced the relaxations evoked by BAY 41-2272. In addition, BAY 41-2272 increased the duration of nitrergic relaxations by approximately 55%. The relaxations induced by glyceryl trinitrate were also significantly potentiated by BAY 41-2272. In conclusion, BAY 41-2272 interacts with endogenous and exogenous NO causing a potent relaxation of rat anococcygeus muscle. (c) 2005 Elsevier B.V. All rights reserved.
dc.description530
dc.description41671
dc.description157
dc.description165
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectanococcygeus muscle
dc.subjectBAY 41-2272
dc.subjectsoluble guanylyl cyclase
dc.subjecttadalafil
dc.subjectnitric oxide
dc.subjectnitrergic nerve
dc.subjectDependent Protein-kinase
dc.subjectRabbit Corpus Cavernosum
dc.subjectRat Anococcygeus
dc.subjectCyclic-gmp
dc.subjectNerve-stimulation
dc.subjectIn-vitro
dc.subjectActivator
dc.subjectBay-41-2272
dc.subjectInhibition
dc.subjectYc-1
dc.titleStimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: Interaction with nitric oxide
dc.typeArtículos de revistas


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