Benzocaine-loaded polymeric nanocapsules: Study of the anesthetic activities

dc.creatorDe Melo, NFS
dc.creatorDe Araujo, DR
dc.creatorGrillo, R
dc.creatorMoraes, CM
dc.creatorDe Matos, AP
dc.creatorde Paula, E
dc.creatorRosa, AH
dc.creatorFraceto, LF
dc.date2012
dc.dateMAR
dc.date2014-07-30T13:51:49Z
dc.date2015-11-26T16:41:10Z
dc.date2014-07-30T13:51:49Z
dc.date2015-11-26T16:41:10Z
dc.date.accessioned2018-03-28T23:25:18Z
dc.date.available2018-03-28T23:25:18Z
dc.identifierJournal Of Pharmaceutical Sciences. Wiley-blackwell, v. 101, n. 3, n. 1157, n. 1165, 2012.
dc.identifier0022-3549
dc.identifierWOS:000299074300025
dc.identifier10.1002/jps.22829
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55414
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55414
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272842
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThis paper describes a comparison of different polymeric nanocapsules (NCs) prepared with the polymers poly(d,l-lactide-co-glycolide), poly(l-lactide) (PLA), and poly(e-caprolactone) and used as carrier systems for the local anesthetic (LA) benzocaine (BZC). The systems were characterized and their anesthetic activities investigated. The results showed particle size distributions with polydispersity indices below 0.135, average diameters up to 120nm, zeta potentials up to -30mV, and entrapment efficiencies around 70%. Formulations of BZC using the polymeric NCs presented slower release profiles, compared with that of free BZC. Slowest release (release constant, k = 0.0016min(-1)) was obtained using the PLA NC system. Pharmacological evaluation showed that encapsulation of BZC in PLA NCs prolonged its anesthetic action. This new formulation could potentially be used in future applications involving the gradual release of local anesthetics (LAs). (c) 2011 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:11571165, 2012
dc.description101
dc.description3
dc.description1157
dc.description1165
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionNational Council for Research and Technological Development
dc.descriptionFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [06-00121-9, 07/00127-0]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationJournal Of Pharmaceutical Sciences
dc.relationJ. Pharm. Sci.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectbenzocaine
dc.subjectpolymeric nanocapsule
dc.subjectbiodegradable polymers
dc.subjectlocal anesthetic
dc.subjectin vivo
dc.subjectanalgesia
dc.subjectcontrolled release
dc.subjectpoly(lactic
dc.subjectglycolic) acid (PLGA
dc.subjectPLA)
dc.subjectnanocapsules
dc.subjectnanotechnology
dc.subjectMicelle-like Nanoparticles
dc.subjectPla-peg Nanoparticles
dc.subjectSciatic-nerve Block
dc.subjectDrug Incorporation
dc.subjectBiodegradable Nanospheres
dc.subjectChemotherapeutic Carrier
dc.subjectPlga Nanoparticles
dc.subjectLocal-anesthetics
dc.subjectRelease
dc.subjectDelivery
dc.titleBenzocaine-loaded polymeric nanocapsules: Study of the anesthetic activities
dc.typeArtículos de revistas


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