beta-Cell Function Improvements in Grade I/II Obese Subjects With Type 2 Diabetes 1 Month After Biliopancreatic Diversion Results from modeling analyses of oral glucose tolerance tests and hyperglycemic clamp studies

dc.creatorVasques, ACJ
dc.creatorPareja, JC
dc.creatorde Oliveira, MD
dc.creatorNovaes, FS
dc.creatorLima, MMD
dc.creatorChaim, EA
dc.creatorPiccinini, F
dc.creatorDalla Man, C
dc.creatorCobelli, C
dc.creatorGeloneze, B
dc.date2013
dc.dateDEC
dc.date2014-07-30T13:51:51Z
dc.date2015-11-26T16:41:06Z
dc.date2014-07-30T13:51:51Z
dc.date2015-11-26T16:41:06Z
dc.date.accessioned2018-03-28T23:25:13Z
dc.date.available2018-03-28T23:25:13Z
dc.identifierDiabetes Care. Amer Diabetes Assoc, v. 36, n. 12, n. 4117, n. 4124, 2013.
dc.identifier0149-5992
dc.identifier1935-5548
dc.identifierWOS:000327211500066
dc.identifier10.2337/dc13-0530
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55429
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55429
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272822
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionOBJECTIVETo investigate the effect of biliopancreatic diversion (BPD) surgery on -cell function in grade I and II obese patients with type 2 diabetes using oral and intravenous glucose loads.RESEARCH DESIGN AND METHODSSixty-eight women were divided into the following three groups: 19 lean-control (23.0 2.2 kg/m(2)) and 18 obese-control (35.0 4.8 kg/m(2)) subjects with normal glucose tolerance, and 31 obese patients with type 2 diabetes (36.3 +/- 3.7 kg/m(2)). Of the 31 diabetic women, 64% underwent BPD (n = 20, BMI: 36.5 +/- 3.7 kg/m(2)) and were reassessed 1 month after surgery. Oral glucose tolerance tests and hyperglycemic clamps were performed. Mathematical modeling was used to analyze basal and stimulated -cell function, insulin sensitivity (IS), hepatic extraction (HE) of insulin, and delay time of -cell response to a specific plasma glucose concentration.RESULTSAfter BPD, restoration of the basal disposition index (P < 0.001) and improvement of the stimulated disposition indices in oral and intravenous glucose stimulation of the -cell were observed (P < 0.05). In both dynamic tests, there were no changes in the delay time of -cell response. IS for oral glucose stimulation (ISoral) and intravenous clamp glucose stimulation (ISclamp) was completely normalized (P < 0.001). ISoral and ISclamp increased approximately 5.0-fold and 3.5-fold, respectively (P < 0.01). The HE of insulin increased in the basal (P < 0.05) and stimulated states (P < 0.01).CONCLUSIONS-Cell function, IS, and HE of insulin improved after BPD, which improved glycemic control.
dc.description36
dc.description12
dc.description4117
dc.description4124
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionEthicon Endo-Surgery Group
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2008/09451-7, 2008/07312-0]
dc.languageen
dc.publisherAmer Diabetes Assoc
dc.publisherAlexandria
dc.publisherEUA
dc.relationDiabetes Care
dc.relationDiabetes Care
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectHepatic Insulin Extraction
dc.subjectGlucagon-like Peptide-1
dc.subjectY Gastric Bypass
dc.subjectFree Fatty-acids
dc.subjectBariatric Surgery
dc.subjectMinimal Model
dc.subjectWeight-loss
dc.subjectMorbid-obesity
dc.subjectSensitivity
dc.subjectResistance
dc.titlebeta-Cell Function Improvements in Grade I/II Obese Subjects With Type 2 Diabetes 1 Month After Biliopancreatic Diversion Results from modeling analyses of oral glucose tolerance tests and hyperglycemic clamp studies
dc.typeArtículos de revistas


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