Chemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities

dc.creatorCosta, EV
dc.creatorDutra, LM
dc.creatorSalvador, MJ
dc.creatorRibeiro, LHG
dc.creatorGadelha, FR
dc.creatorde Carvalho, JE
dc.date2013
dc.date37043
dc.date2014-07-30T16:52:17Z
dc.date2015-11-26T16:40:38Z
dc.date2014-07-30T16:52:17Z
dc.date2015-11-26T16:40:38Z
dc.date.accessioned2018-03-28T23:24:39Z
dc.date.available2018-03-28T23:24:39Z
dc.identifierNatural Product Research. Taylor & Francis Ltd, v. 27, n. 11, n. 997, n. 1001, 2013.
dc.identifier1478-6419
dc.identifierWOS:000320641900007
dc.identifier10.1080/14786419.2012.686913
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63000
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63000
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272706
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe essential oils from the leaves of Annona pickelii and Annona salzmannii (Annonaceae) were obtained by hydrodistillation using a Clevenger apparatus, and analysed by GC-MS and GC-FID. A total of 21 compounds were identified in the essential oil of A. pickelii and 23 in that of A. salzmannii; sesquiterpenes predominated in both essential oils. Bicyclogermacrene (38.0%), (E)-caryophyllene (27.8%), -copaene (6.9%) and -humulene (4.0%) were the main components of A. pickelii, while -cadinene (22.6%), (E)-caryophyllene (21.4%), -copaene (13.3%), bicyclogermacrene (11.3%) and germacrene D (6.9%) were the main components of A. salzmannii. The biological activities of the essential oils against Trypanosoma cruzi epimastigote forms and cytotoxicity against tumour cell lines (antitumour) were investigated. The essential oils showed potent trypanocidal and antitumour activities with values of IC50 lower than 100 mu gmL(-1).
dc.description27
dc.description11
dc.description997
dc.description1001
dc.descriptionFAPITEC/SE [Editais 07/2009, 10/2009]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFAEPEX-UNICAMP
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPITEC/SE [Editais 07/2009, 10/2009]
dc.languageen
dc.publisherTaylor & Francis Ltd
dc.publisherAbingdon
dc.publisherInglaterra
dc.relationNatural Product Research
dc.relationNat. Prod. Res.
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectAnnona pickelii
dc.subjectAnnona salzmannii
dc.subjectessential oil
dc.subjectantitumour and trypanocidal activities
dc.subjectTrypanosoma-cruzi
dc.subjectLeaves
dc.titleChemical composition of the essential oils of Annona pickelii and Annona salzmannii (Annonaceae), and their antitumour and trypanocidal activities
dc.typeArtículos de revistas


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