Epileptic seizures in systemic lupus erythematosus

dc.creatorAppenzeller, S
dc.creatorCendes, F
dc.creatorCostallat, LTL
dc.date2004
dc.date45231
dc.date2014-07-30T17:27:24Z
dc.date2015-11-26T16:39:27Z
dc.date2014-07-30T17:27:24Z
dc.date2015-11-26T16:39:27Z
dc.date.accessioned2018-03-28T23:23:04Z
dc.date.available2018-03-28T23:23:04Z
dc.identifierNeurology. Lippincott Williams & Wilkins, v. 63, n. 10, n. 1808, n. 1812, 2004.
dc.identifier0028-3878
dc.identifierWOS:000225275000009
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65501
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65501
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272481
dc.descriptionObjective: To evaluate the frequency and risk factors of epileptic seizures in a large cohort of patients with systemic lupus erythematosus (SLE). Methods: Five hundred nineteen consecutive patients with SLE were studied, with follow-up ranging from 4 to 7.8 years. The type and frequency of risk factors associated with acute and recurrent epileptic seizures in SLE were determined. Results: Sixty (11.6%) patients with epileptic seizures were identified. Epileptic seizures occurred at the onset of SLE symptoms in 19 (31.6%) and after the onset of SLE in 41 of 60 (68.3%) patients. Fifty-three of 60 (88.3%) patients had acute symptomatic epileptic seizures, and 7 of 60 (11.7%) had recurrent epileptic seizures. Variables associated with acute epileptic seizures at SLE onset were stroke (p=0.0004) and antiphospholipid antibodies (p=0.0013). Epileptic seizures during follow-up were related to nephritis (p=0.001), antiphospholipid antibodies (p=0.005), and epileptic seizures at disease onset (p=0.00001). All seven patients who presented recurrent epileptic seizures had antiphospholipid syndrome and interictal epileptic abnormalities on EEG. Conclusions: Epileptic seizures were observed in 11.2% of systemic lupus erythematosus (SLE) patients. Antiphospholipid antibodies and stroke were related to epileptic seizures at SLE disease onset. Patients with renal flares, epileptic seizures at SLE disease onset, and antiphospholipid antibodies were at greater risk for acute symptomatic seizures during follow-up. Recurrence of epileptic seizures occurred in 1.3% of patients and was associated with antiphospholipid syndrome.
dc.descriptiono TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.
dc.description63
dc.description10
dc.description1808
dc.description1812
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationNeurology
dc.relationNeurology
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectCentral-nervous-system
dc.subjectAntiphospholipid Antibodies
dc.subjectNeuropsychiatric Manifestations
dc.subjectAnticardiolipin Antibodies
dc.subjectDisease
dc.subjectAssociation
dc.subjectPrevalence
dc.subjectClassification
dc.subjectAnticoagulants
dc.subjectDefinitions
dc.titleEpileptic seizures in systemic lupus erythematosus
dc.typeArtículos de revistas


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