Pharmacological characterization of the mouse paw edema induced by staphylococcal enterotoxin B

dc.creatorDesouza, IA
dc.creatorBergdoll, MS
dc.creatorRiberioDaSilva, G
dc.date1996
dc.dateFEB
dc.date2014-07-30T14:31:23Z
dc.date2015-11-26T16:39:01Z
dc.date2014-07-30T14:31:23Z
dc.date2015-11-26T16:39:01Z
dc.date.accessioned2018-03-28T23:22:33Z
dc.date.available2018-03-28T23:22:33Z
dc.identifierJournal Of Natural Toxins. Alaken, Inc, v. 5, n. 1, n. 61, n. 71, 1996.
dc.identifier1058-8108
dc.identifierWOS:A1996TW83400006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59411
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59411
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272370
dc.descriptionStaphylococcal enterotoxin B (SEE) induced a long-lasting dose- and time-dependent edema in the mouse hind paw. The edematogenic response was biphasic and consisted of a primary (early) phase which lasted approximately 24 h and a secondary (late) phase which started after 24 h and continued for up to 72 h. There was a positive correlation between the measured edema and the amount of Evans blue dye extravasation produced by SEE, suggesting that this exudate is the principal component of the edema. Arachidonic acid metabolites contribute to the SEE-induced edema with lipoxygenase products being involved in the early phase, while cyclooxygenase products are involved in the late phase. The early phase edema was partially prevented by pretreating the mice with WEB 2086 (a PAF antagonist), capsaicin (to deplete sensory C-fibers of their neuropeptides), or histamine receptor (H-1 or H-2) antagonists. Based on the similarities between the SEE-induced edema in mice and the vomiting and cutaneous ''pseudoallergy'' produced by this toxin in monkeys, our results suggest that mice may prove to be a useful model for studying SE-mediated enterotoxemia.
dc.description5
dc.description1
dc.description61
dc.description71
dc.languageen
dc.publisherAlaken, Inc
dc.publisherFt Collins
dc.relationJournal Of Natural Toxins
dc.relationJ. Nat. Toxins
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectPlatelet Activating Factor
dc.subjectCysteinyl Leukotrienes
dc.subjectArachidonic-acid
dc.subjectUnsensitized Monkeys
dc.subjectInflammation
dc.subjectMediators
dc.subjectSkin
dc.subjectAntagonist
dc.subjectInhibition
dc.titlePharmacological characterization of the mouse paw edema induced by staphylococcal enterotoxin B
dc.typeArtículos de revistas


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