Transfer of clarithromycin to gastric juice is enhanced by omeprazole in Helicobacter pylori-infected individuals

dc.creatorPedrazzoli, J
dc.creatorCalafatti, SA
dc.creatorOrtiz, RAM
dc.creatorDias, FE
dc.creatorDeguer, M
dc.creatorMendes, FD
dc.creatorBento, AP
dc.creatorPereira, AA
dc.creatorPiovesana, H
dc.creatorFerraz, JGP
dc.creatorLerner, F
dc.creatorde Nucci, G
dc.date2001
dc.dateDEC
dc.date2014-12-02T16:29:05Z
dc.date2015-11-26T16:38:33Z
dc.date2014-12-02T16:29:05Z
dc.date2015-11-26T16:38:33Z
dc.date.accessioned2018-03-28T23:21:57Z
dc.date.available2018-03-28T23:21:57Z
dc.identifierScandinavian Journal Of Gastroenterology. Taylor & Francis As, v. 36, n. 12, n. 1248, n. 1253, 2001.
dc.identifier0036-5521
dc.identifierWOS:000172008500003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77540
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77540
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77540
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272281
dc.descriptionBackground: The effects of proton-pump inhibitors and Helicobacter pylori infection on the distribution of drugs employed for the eradication of H. pylori are poorly understood. The aim of this study was to investigate the effects of a 7-day oral administration of 20 mg omeprazole on the distribution of clarithromycin in the gastric juice of individuals with H. pylori infection. Methods: Eighteen H. pylori-infected dyspeptic male volunteers without endoscopic lesions were enrolled in a study with an open, randomized, two-period crossover design and a 21-day washout period between phases. Plasma and gastric juice concentrations of clarithromycin in subjects with and without omeprazole pretreatment were measured by means of liquid chromatography coupled to tandem mass spectrometry. Results: The maximum concentration of clarithromycin (C-max) and the area under the time-concentration curve from 0 to 2 h (AUC(0-2h)) were significantly higher in gastric juice than in plasma. Omeprazole treatment further augmented clarithromycin C-max and AUC(0-2h) in gastric juice approximately 2-fold (P < 0.05). Conclusions: Short-term treatment with omeprazole in H. pylori-positive volunteers increases the amount of clarithromycin transferred to the gastric juice, confirming a synergism between these drugs. Our results suggest the presence of an active transport mechanism for clarithromycin from plasma to the gastric lumen, which is influenced by omeprazole.
dc.description36
dc.description12
dc.description1248
dc.description1253
dc.languageen
dc.publisherTaylor & Francis As
dc.publisherOslo
dc.publisherNoruega
dc.relationScandinavian Journal Of Gastroenterology
dc.relationScand. J. Gastroenterol.
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectClarithromycin
dc.subjectHelicobacter pylori
dc.subjectomeprazole
dc.subjectpeptic ulcer
dc.subjectpharmacokinetics
dc.subjectAcid-secretion
dc.subjectUlcer Disease
dc.subjectMetronidazole
dc.subjectAmoxicillin
dc.subjectEradication
dc.subjectSusceptibility
dc.subjectTherapies
dc.titleTransfer of clarithromycin to gastric juice is enhanced by omeprazole in Helicobacter pylori-infected individuals
dc.typeArtículos de revistas


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