Eicosapentaenoic acid decreases TNF-alpha and protects dystrophic muscles of mdx mice from degeneration

dc.creatorMachado, RV
dc.creatorMauricio, AF
dc.creatorTaniguti, APT
dc.creatorFerretti, R
dc.creatorNeto, HS
dc.creatorMarques, MJ
dc.date2011
dc.dateMAR
dc.date2014-07-30T17:24:16Z
dc.date2015-11-26T16:38:21Z
dc.date2014-07-30T17:24:16Z
dc.date2015-11-26T16:38:21Z
dc.date.accessioned2018-03-28T23:21:38Z
dc.date.available2018-03-28T23:21:38Z
dc.identifierJournal Of Neuroimmunology. Elsevier Science Bv, v. 232, n. 41671, n. 145, n. 150, 2011.
dc.identifier0165-5728
dc.identifierWOS:000289493700019
dc.identifier10.1016/j.jneuroim.2010.10.032
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65388
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65388
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272244
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn dystrophin-deficient fibers of mdx mice and in Duchenne muscular dystrophy, inflammation and increased production of tumor necrosis factor alpha (TNF-alpha) contribute to myonecrosis. We examined the effects of eicosapentaenoic acid (EPA) on dystrophic muscle degeneration. Mdx mice (14 days old) received EPA for 16 days. The sternomastoid, diaphragm and biceps brachii muscles were removed. Control mdx mice received vehicle. EPA decreased creatine kinase and myonecrosis and reduced the levels of TNF-alpha. These results suggest that EPA plays a protective role in dystrophic muscle degeneration, possibly by reducing TNF-alpha, and support further investigations of EPA as a potential therapy for dystrophinopathies. (C) 2010 Elsevier B.V. All rights reserved.
dc.description232
dc.description41671
dc.description145
dc.description150
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [08/58491-1]
dc.descriptionCNPq [301386/2007-2, 302006/2009-5]
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationJournal Of Neuroimmunology
dc.relationJ. Neuroimmunol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectEPA
dc.subjectDuchenne dystrophy
dc.subjectmdx mice
dc.subjectMuscle degeneration
dc.subjectSarcolemma leakiness
dc.subjectTNF-alpha
dc.subjectDuchenne Muscular-dystrophy
dc.subjectTumor-necrosis-factor
dc.subjectPolyunsaturated Fatty-acids
dc.subjectFish-oil
dc.subjectSkeletal-muscle
dc.subjectInflammatory Processes
dc.subjectDeficient Muscle
dc.subjectWeight-loss
dc.subjectKappa-b
dc.subjectMouse
dc.titleEicosapentaenoic acid decreases TNF-alpha and protects dystrophic muscles of mdx mice from degeneration
dc.typeArtículos de revistas


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