Influence of hemodilution on the renal blood flow autoregulation during acute expansion in rats

dc.creatorFranchini, KG
dc.date1999
dc.dateDEC
dc.date2014-12-02T16:28:37Z
dc.date2015-11-26T16:37:24Z
dc.date2014-12-02T16:28:37Z
dc.date2015-11-26T16:37:24Z
dc.date.accessioned2018-03-28T23:20:30Z
dc.date.available2018-03-28T23:20:30Z
dc.identifierAmerican Journal Of Physiology-regulatory Integrative And Comparative Physiology. Amer Physiological Soc, v. 277, n. 6, n. R1662, n. R1674, 1999.
dc.identifier0363-6119
dc.identifierWOS:000084225100016
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80173
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/80173
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80173
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1272012
dc.descriptionAutoregulation of renal blood flow (RBP) was studied in rats that underwent equivalent blood volume expansion with saline (Sal; 5% body wt), 7% BSA solution (1.4% body wt), and reconstituted whole blood from donor rats (WBL; 1.4% body wt). Renal perfusion pressure (RPP) and renal neural reflexes were prevented by clamping RPP and sectioning the vagus, baro/chemoreceptor, and renal nerves. Sal and BSA expansion increased RBF by similar to 60%, whereas no effect was observed with WBL. RBF autoregulation was markedly attenuated after expansion with cell-free solutions, but no change occurred in WBL-expanded rats. Correction of the fall in hematocrit in Sal- and BSA-expanded rats restored RBF and its autoregulation to control levels. Expansion with Sal or BSA after inhibition of renal vascular tone with intrarenal infusion of papaverine still increased RBF and further changed the RBF-RPP relationship. These findings suggest that the hemodilution plays a central role in the reduction of renal vascular resistance and in the attenuation of the autoregulatory efficiency of renal circulation that accompany expansion with cell-free solutions.
dc.descriptiono TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.
dc.description277
dc.description6
dc.descriptionR1662
dc.descriptionR1674
dc.languageen
dc.publisherAmer Physiological Soc
dc.publisherBethesda
dc.publisherEUA
dc.relationAmerican Journal Of Physiology-regulatory Integrative And Comparative Physiology
dc.relationAm. J. Physiol.-Regul. Integr. Comp. Physiol.
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectrenal circulation
dc.subjectblood rheology
dc.subjectvolume expansion
dc.subjectAcute Volume Expansion
dc.subjectNitric-oxide
dc.subjectTubuloglomerular Feedback
dc.subjectGlomerular Ultrafiltration
dc.subjectSodium-excretion
dc.subjectHemodynamics
dc.subjectArterioles
dc.subjectResistance
dc.subjectDependence
dc.subjectFiltration
dc.titleInfluence of hemodilution on the renal blood flow autoregulation during acute expansion in rats
dc.typeArtículos de revistas


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