A dipeptide and an amino acid present in whey protein hydrolysate increase translocation of GLUT-4 to the plasma membrane in Wistar rats

dc.creatorMorato, PN
dc.creatorLollo, PCB
dc.creatorMoura, CS
dc.creatorBatista, TM
dc.creatorCarneiro, EM
dc.creatorAmaya-Farfan, J
dc.date2013
dc.date37073
dc.date2014-07-30T13:39:35Z
dc.date2015-11-26T16:36:28Z
dc.date2014-07-30T13:39:35Z
dc.date2015-11-26T16:36:28Z
dc.date.accessioned2018-03-28T23:19:12Z
dc.date.available2018-03-28T23:19:12Z
dc.identifierFood Chemistry. Elsevier Sci Ltd, v. 139, n. 41730, n. 853, n. 859, 2013.
dc.identifier0308-8146
dc.identifierWOS:000318200900113
dc.identifier10.1016/j.foodchem.2012.12.062
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53118
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/53118
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271825
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionWhey protein hydrolysate (WPH) is capable of increasing muscle glycogen reserves and of concentrating the glucose transporter in the plasma membrane (PM). The objective of this study was to determine which WPH components could modulate translocation of the glucose transporter GLUT-4 to the PM of animal skeletal muscle. Forty-nine animals were divided into 7 groups (n = 7) and received by oral gavage 30% glucose plus 0.55 g/kg body mass of the following WPH components: (a) control; (b) WPH; (c) L-isoleucine; (d) L-leucine; (e) L-leucine plus L-isoleucine; (f) L-isoleucyl-L-leucine dipeptide; (g) L-leucyl-L-isoleucine dipeptide. After receiving these solutions, the animals were sacrificed and the GLUT-4 analysed by western blot. Additionally, glycogen, glycaemia, insulin and free amino acids were also determined by standard methods. Of the WPH components tested, the amino acid L-isoleucine and the peptide L-leucyl-L-isoleucine showed greater efficiency in translocating GLUT-4 to the PM and of increasing glucose capture by skeletal muscle. (c) 2013 Elsevier Ltd. All rights reserved.
dc.description139
dc.description41730
dc.description853
dc.description859
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFAPESP [Proc. 2012/05859-7]
dc.languageen
dc.publisherElsevier Sci Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationFood Chemistry
dc.relationFood Chem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectL-Leucyl-L-isoleucine
dc.subjectL-Isoleucine
dc.subjectGlucose transporter
dc.subjectPeptides
dc.subjectBranched-chain amino acids
dc.subjectExercise-trained Rats
dc.subjectMuscle Glucose-uptake
dc.subjectSkeletal-muscle
dc.subjectGlycogen-storage
dc.subjectInsulin
dc.subjectExpression
dc.subjectIsoleucine
dc.subjectKinase
dc.subjectLiver
dc.subjectMedicine
dc.titleA dipeptide and an amino acid present in whey protein hydrolysate increase translocation of GLUT-4 to the plasma membrane in Wistar rats
dc.typeArtículos de revistas


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