Screening of Formulation Variables for the Preparation of Poly(epsilon-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaine

dc.creatorMoraes, CM
dc.creatorde Matos, AP
dc.creatorGrillo, R
dc.creatorde Melo, NFS
dc.creatorde Paula, E
dc.creatorDias, NL
dc.creatorRosa, AH
dc.creatorFraceto, LF
dc.date2011
dc.dateMAR
dc.date2014-07-30T18:35:44Z
dc.date2015-11-26T16:35:57Z
dc.date2014-07-30T18:35:44Z
dc.date2015-11-26T16:35:57Z
dc.date.accessioned2018-03-28T23:18:35Z
dc.date.available2018-03-28T23:18:35Z
dc.identifierJournal Of Nanoscience And Nanotechnology. Amer Scientific Publishers, v. 11, n. 3, n. 2450, n. 2457, 2011.
dc.identifier1533-4880
dc.identifierWOS:000288102300090
dc.identifier10.1166/jnn.2011.3547
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71556
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71556
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271680
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn this work we describe the screening of four parameters in the preparation, by nanoprecipitation, of poly(epsilon-caprolactone) nanocapsules, used as a drug carrier system for the local anesthetic, benzocaine. A 2(4-1) factorial experimental design was used to study the influence of four different independent variables (polymer, oily phase, Span 60 and Tween 80) on nanocapsule characteristics (size, polydispersion index, zeta potential) and drug loading capability. Best results were obtained using an aqueous formulation comprising 100 mg of polymer, 200 mg of oily phase, 40 mg of Span 60 and 60 mg of Tween 80 in a final volume of 10 mL which produced a colloidal system with particle size of 188 nm, zeta potential -32 mV, polydispersion index 0.07, and benzocaine association efficiency > 87%. These findings open the way for future clinical studies using such formulations.
dc.description11
dc.description3
dc.description2450
dc.description2457
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [06-00121-9, 07/00127-0]
dc.languageen
dc.publisherAmer Scientific Publishers
dc.publisherStevenson Ranch
dc.publisherEUA
dc.relationJournal Of Nanoscience And Nanotechnology
dc.relationJ. Nanosci. Nanotechnol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectExperimental Design
dc.subject2(4-1) Factorial Experimental
dc.subjectNanoparticles
dc.subjectPolymeric Nanocapsules
dc.subjectLocal Anesthetic
dc.subjectFactorial Design
dc.subjectPlga Nanoparticles
dc.subjectPhysicochemical Characterization
dc.subjectSpontaneous Emulsification
dc.subjectDrug Incorporation
dc.subjectOptimization
dc.subjectDiffusion
dc.subjectSolvent
dc.subjectNanospheres
dc.subjectStability
dc.titleScreening of Formulation Variables for the Preparation of Poly(epsilon-caprolactone) Nanocapsules Containing the Local Anesthetic Benzocaine
dc.typeArtículos de revistas


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