Pattern of cytokine secretion by peripheral blood cells of patients with multiple sclerosis in Brazil

dc.creatorda Costa, PM
dc.creatorYasuda, CL
dc.creatorScagliusi, SM
dc.creatorDiaz-Bardales, BM
dc.creatorMaciel, E
dc.creatorDamasceno, BP
dc.creatorBlotta, MHSL
dc.creatorTilbery, CP
dc.creatorSantos, LMB
dc.date2000
dc.dateOCT
dc.date2014-12-02T16:28:03Z
dc.date2015-11-26T16:35:47Z
dc.date2014-12-02T16:28:03Z
dc.date2015-11-26T16:35:47Z
dc.date.accessioned2018-03-28T23:18:21Z
dc.date.available2018-03-28T23:18:21Z
dc.identifierMultiple Sclerosis. Nature Publishing Group, v. 6, n. 5, n. 293, n. 299, 2000.
dc.identifier1352-4585
dc.identifierWOS:000089837700001
dc.identifier10.1177/135245850000600501
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59156
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/59156
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59156
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271622
dc.descriptionAutoimmune T cells play a key role as regulators and effecters of organ-specific autoimmune disease. In multiple sclerosis (MS), activated T cells specific for myelin components produce a plethora of inflammatory cytokines and mediators that contribute to myelin damage. The production of proinflammatory and regulatory cytokines by peripheral blood cells from patients with active and stable MS and healthy controls were examined The results show that TNF alpha production was somewhat elevated in active MS with no significant increase in the level IFN gamma, whereas in the chronic phase the anti-inflammatory cytokines IL-10 and TGF-beta increased, accompanied by a reduction in IFN gamma when stimulated by myelin basic protein.
dc.description6
dc.description5
dc.description293
dc.description299
dc.languageen
dc.publisherNature Publishing Group
dc.publisherBasingstoke
dc.publisherInglaterra
dc.relationMultiple Sclerosis
dc.relationMult. Scler.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectcytokines
dc.subjectmyelin basic protein
dc.subjectautoimmunity
dc.subjectMyelin Basic-protein
dc.subjectTumor-necrosis-factor
dc.subjectExperimental Autoimmune Encephalomyelitis
dc.subjectExperimental Allergic Encephalomyelitis
dc.subjectMessenger-rna Expression
dc.subjectCentral-nervous-system
dc.subjectTgf-beta
dc.subjectT-cells
dc.subjectInterferon-gamma
dc.subjectOral Tolerance
dc.titlePattern of cytokine secretion by peripheral blood cells of patients with multiple sclerosis in Brazil
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución