Detection of human papillomavirus in laryngeal squamous dysplasia and carcinoma. An in situ hybridization and signal amplification study

dc.creatorBrito, H
dc.creatorVassallo, J
dc.creatorAltemani, A
dc.date2000
dc.dateJUN
dc.date2014-12-02T16:28:38Z
dc.date2015-11-26T16:35:44Z
dc.date2014-12-02T16:28:38Z
dc.date2015-11-26T16:35:44Z
dc.date.accessioned2018-03-28T23:18:17Z
dc.date.available2018-03-28T23:18:17Z
dc.identifierActa Oto-laryngologica. Taylor & Francis As, v. 120, n. 4, n. 540, n. 544, 2000.
dc.identifier0001-6489
dc.identifierWOS:000088308600015
dc.identifier10.1080/000164800750046072
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61314
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61314
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61314
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271606
dc.descriptionWe examined the presence of human papillomavirus (HPV) DNA in 65 cases of laryngeal squamous dysplasia and carcinomas using in situ hybridization with signal amplification in paraffin sections. Hybridization was performed with biotynilated DNA probes for HPV 6/11, 16/18, 31/33 and wide-spectrum HPV (6, 11, 16, 30, 31, 45, 51 and 52). HPV DNA was found in 7 cases of the total sample (10.7%); it was also found in 4 out of 45 (8.8%) cases of invasive carcinoma and in 5 out of 33 (15.5%) cases of squamous dysplasia. Morphological signs suggestive of HPV infection were observed in 35.5% of our sample but they were not related to HPV DNA positivity. In conclusion, HPV probably plays little, if any, role in laryngeal carcinogenesis among the population studied.
dc.description120
dc.description4
dc.description540
dc.description544
dc.languageen
dc.publisherTaylor & Francis As
dc.publisherOslo
dc.publisherNoruega
dc.relationActa Oto-laryngologica
dc.relationActa Oto-Laryngol.
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectcarcinogenesis
dc.subjectlarynx
dc.subjectpapillomavirus
dc.subjectviral infection
dc.subjectPolymerase Chain-reaction
dc.subjectCell Carcinomas
dc.subjectHpv
dc.subjectPrevalence
dc.subjectLesions
dc.subjectInsitu
dc.subjectCancer
dc.subjectHead
dc.subjectDna
dc.titleDetection of human papillomavirus in laryngeal squamous dysplasia and carcinoma. An in situ hybridization and signal amplification study
dc.typeArtículos de revistas


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