Extensive Skin Necrosis Induced by Low-Molecular-Weight Heparin in a Patient With Systemic Lupus Erythematosus and Antiphospholipid Syndrome

dc.creatorYazbek, MA
dc.creatorVelho, P
dc.creatorNadruz, W
dc.creatorMahayri, N
dc.creatorAppenzeller, S
dc.creatorCostallat, LTL
dc.date2012
dc.dateJUN
dc.date2014-07-30T17:34:10Z
dc.date2015-11-26T16:35:25Z
dc.date2014-07-30T17:34:10Z
dc.date2015-11-26T16:35:25Z
dc.date.accessioned2018-03-28T23:17:53Z
dc.date.available2018-03-28T23:17:53Z
dc.identifierJcr-journal Of Clinical Rheumatology. Lippincott Williams & Wilkins, v. 18, n. 4, n. 196, n. 198, 2012.
dc.identifier1076-1608
dc.identifierWOS:000304811800008
dc.identifier10.1097/RHU.0b013e318258327a
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66544
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66544
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271506
dc.descriptionLow-molecular-weight heparin-induced skin necrosis can occur as a clinical feature of heparin-induced thrombocytopenia syndrome. Heparin-induced thrombocytopenia and antiphospholipid syndromes have some clinical features in common, including thrombocytopenia and thrombotic events. We describe a 46-year-old woman who developed extensive necrosis in the breast and other sites secondary to the use of enoxaparin after an elective hysterectomy. During the postoperative period, diagnoses of systemic lupus erythematosus and antiphospholipid syndrome were made because of some clinical and laboratory features (seizure, nephritis, bicytopenia, positive nuclear antibody, and positive antiphospholipid antibodies with a previous thrombotic event). The patient's clinical course improved only after corticosteroid therapy and the suspension of enoxaparin. Heparin-induced thrombocytopenia and antiphospholipid syndromes can have platelet factor 4 as a common denominator in their pathogenesis because platelet factor 4 tetramers can bind beta(2)-glycoprotein molecules. This case suggests that use of low-molecular-weight heparins could be more risky in patients with an underlying immune disease and/or could trigger immune reactions that must be analyzed in larger studies.
dc.description18
dc.description4
dc.description196
dc.description198
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationJcr-journal Of Clinical Rheumatology
dc.relationJCR-J. Clin. Rheumatol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectskin necrosis
dc.subjectheparin-induced necrosis
dc.subjectheparin
dc.subjectlow-molecular-weight heparin
dc.subjectantiphospholipid syndrome
dc.subjectsystemic lupus erythematosus
dc.titleExtensive Skin Necrosis Induced by Low-Molecular-Weight Heparin in a Patient With Systemic Lupus Erythematosus and Antiphospholipid Syndrome
dc.typeArtículos de revistas


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