| dc.creator | Cesar, LMM | |
| dc.creator | Tormena, CF | |
| dc.creator | Marques, MR | |
| dc.creator | Silva, GVJ | |
| dc.creator | Mendes, MA | |
| dc.creator | Rittner, R | |
| dc.creator | Palma, MS | |
| dc.date | 2005 | |
| dc.date | 2014-07-31T14:22:15Z | |
| dc.date | 2015-11-26T16:35:08Z | |
| dc.date | 2014-07-31T14:22:15Z | |
| dc.date | 2015-11-26T16:35:08Z | |
| dc.date.accessioned | 2018-03-28T23:17:32Z | |
| dc.date.available | 2018-03-28T23:17:32Z | |
| dc.identifier | Helvetica Chimica Acta. Wiley-v C H Verlag Gmbh, v. 88, n. 4, n. 796, n. 801, 2005. | |
| dc.identifier | 0018-019X | |
| dc.identifier | WOS:000228762400007 | |
| dc.identifier | 10.1002/hlca.200590056 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75375 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/75375 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1271417 | |
| dc.description | A new, highly active tetrahydro-p-carboline toxin from the spider Parawixia bistriata, the most-common species of social spider occurring in Brazil, was isolated. The new toxin was identified as 1,2,3,4-tetrahydro-6-hydroxy-beta-carboline (= N-[3-(2,3,4,9-tetrahydro-6-hydroxy-1H-pyrido[3,4-b]indol-1-yl)propyl]guanidine; 3). This type of alkaloid, not common among spider toxins, was found to be the most-potent constituent of the spider's chemical weaponry to kill prey. When P bistriata catch arthropods in their web, they apparently attack their prey in groups of many individuals injecting their venoms. In vivo toxicity assays with 3 demonstrated a potent lethal effect to honeybees, giving rise to clear neurotoxic effects (paralysis) before death. The compound's toxicity (LD50 value) was determined to be ca. 8 ng/g of honeybee. The investigation of the pharmacological properties and neurotoxic actions of 3 may be used in the future for the development of new drugs to be applied for pest control in agriculture. | |
| dc.description | 88 | |
| dc.description | 4 | |
| dc.description | 796 | |
| dc.description | 801 | |
| dc.language | en | |
| dc.publisher | Wiley-v C H Verlag Gmbh | |
| dc.publisher | Weinheim | |
| dc.publisher | Alemanha | |
| dc.relation | Helvetica Chimica Acta | |
| dc.relation | Helv. Chim. Acta | |
| dc.rights | fechado | |
| dc.rights | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
| dc.source | Web of Science | |
| dc.subject | Funnel-web Spider | |
| dc.title | Structure determination of hydroxytrypargine: A new tetrahydro-beta-carboline toxin from the venom of the spider Parawixia bistriata | |
| dc.type | Artículos de revistas | |
