Effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndromes: Induction of IL-10 expression in the stromal layers

dc.creatorLazarini, M
dc.creatorTraina, F
dc.creatorWinnischofer, SM
dc.creatorCosta, FF
dc.creatorQueiroz, MLS
dc.creatorSaad, STO
dc.date2011
dc.dateAUG
dc.date2014-07-30T17:21:49Z
dc.date2015-11-26T16:34:52Z
dc.date2014-07-30T17:21:49Z
dc.date2015-11-26T16:34:52Z
dc.date.accessioned2018-03-28T23:17:12Z
dc.date.available2018-03-28T23:17:12Z
dc.identifierLeukemia Research. Pergamon-elsevier Science Ltd, v. 35, n. 8, n. 1102, n. 1107, 2011.
dc.identifier0145-2126
dc.identifierWOS:000292735300022
dc.identifier10.1016/j.leukres.2011.03.027
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65119
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65119
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271332
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionThe purpose of this study was to investigate the in vitro effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndrome. We demonstrated that thalidomide induced an increase in granulocyte-macrophage colony forming unit numbers and in IL-10 expression. Thalidomide also promoted a slight increase in IL-6, IL-1 beta and TNF-alpha expression in the stromal layers. The numbers of erythroid burst forming units, the apoptosis rate of hematopoietic cells, and VEGF and TNF-alpha expression levels in culture supernatants were not modulated. Our results indicate a participation of thalidomide upon the hematopoietic microenvironment of patients with myelodysplastic syndromes, especially in the up regulation of IL-10. (C) 2011 Elsevier Ltd. All rights reserved.
dc.description35
dc.description8
dc.description1102
dc.description1107
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationLeukemia Research
dc.relationLeuk. Res.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectMyelodysplastic syndromes
dc.subjectBone marrow microenvironment
dc.subjectThalidomide
dc.subjectCytokines
dc.subjectInterleukin-10
dc.subjectNecrosis-factor-alpha
dc.subjectInhibits Cytokine Production
dc.subjectGene-expression
dc.subjectIn-vitro
dc.subjectCells
dc.subjectApoptosis
dc.subjectInterleukin-10
dc.subjectHematopoiesis
dc.subjectLeukemia
dc.subjectMicroenvironment
dc.titleEffects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndromes: Induction of IL-10 expression in the stromal layers
dc.typeArtículos de revistas


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