Prothrombin mutant, factor V Leiden, and thermolabile variant of methylenetetrahydrofolate reductase among patients with sickle cell disease in Brazil

dc.creatorAndrade, FL
dc.creatorAnnichino-Bizzacchi, JM
dc.creatorSaad, STO
dc.creatorCosta, FF
dc.creatorArruda, VR
dc.date1998
dc.dateSEP
dc.date2014-12-02T16:27:45Z
dc.date2015-11-26T16:34:51Z
dc.date2014-12-02T16:27:45Z
dc.date2015-11-26T16:34:51Z
dc.date.accessioned2018-03-28T23:17:10Z
dc.date.available2018-03-28T23:17:10Z
dc.identifierAmerican Journal Of Hematology. Wiley-liss, v. 59, n. 1, n. 46, n. 50, 1998.
dc.identifier0361-8609
dc.identifierWOS:000075517300009
dc.identifier10.1002/(SICI)1096-8652(199809)59:1<46
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58350
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58350
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58350
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271326
dc.descriptionThe prevalence of the prothrombin gene variant (allele 20.210 A), factor V Leiden mutation, and homozygosity for transition 677C-->T in the methylenetetrahydrofolate reductase (MTHFR) gene was determined among patients with sickle cell disease (SCD), The group included 73 patients with median age of 32.3 years with a diagnosis of sickle cell anemia in 53 patients, hemoglobinopathy SC in 16 patients, and four with S/beta(0) thalassemia, Vascular complications such as ischemic stroke or deep vein thrombosis were diagnosed in nine patients. Heterozygosity for the prothrombin gene variant or factor V Leiden mutation was identified in four patients. However, only one patient, who developed ischemic stroke, was identified as a carrier of factor V Leiden mutation. None of the patients presented homozygosity for the thermolabile variant of the MTHFR, These data suggest a low clinical impact of inherited hypercoagulability risk factors in developing thrombosis, occlusive stroke, or mortality data among patients with SCD in Brazil. (C) 1998 Wiley-Liss, Inc.
dc.description59
dc.description1
dc.description46
dc.description50
dc.languageen
dc.publisherWiley-liss
dc.publisherNew York
dc.publisherEUA
dc.relationAmerican Journal Of Hematology
dc.relationAm. J. Hematol.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectfactor V gene
dc.subjectprothrombin gene
dc.subjecthomocysteine
dc.subjectsickle cell disease
dc.subjectthrombosis
dc.subjectActivated Protein-c
dc.subjectCoagulation-factor-v
dc.subjectVenous Thrombosis
dc.subjectArterial-disease
dc.subjectInherited Thrombophilia
dc.subjectMyocardial-infarction
dc.subjectVascular-disease
dc.subjectRisk Factor
dc.subjectMutation
dc.subjectStroke
dc.titleProthrombin mutant, factor V Leiden, and thermolabile variant of methylenetetrahydrofolate reductase among patients with sickle cell disease in Brazil
dc.typeArtículos de revistas


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