Protein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats

dc.creatorLatorraca, MQ
dc.creatorReis, MAB
dc.creatorCarneiro, EM
dc.creatorMello, MAR
dc.creatorVelloso, LA
dc.creatorSaad, MJA
dc.creatorBoschero, AC
dc.date1998
dc.dateOCT
dc.date2014-12-02T16:27:39Z
dc.date2015-11-26T16:34:43Z
dc.date2014-12-02T16:27:39Z
dc.date2015-11-26T16:34:43Z
dc.date.accessioned2018-03-28T23:17:00Z
dc.date.available2018-03-28T23:17:00Z
dc.identifierJournal Of Nutrition. Amer Inst Nutrition, v. 128, n. 10, n. 1643, n. 1649, 1998.
dc.identifier0022-3166
dc.identifierWOS:000076210700010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58323
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58323
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58323
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271282
dc.descriptionMaternal malnutrition was shown to affect early growth and leads to permanent alterations in insulin secretion and sensitivity of offspring. In addition, epidemiological studies showed an association between low birth weight and glucose intolerance in adult life. To understand these interactions better, we investigated the insulin secretion by isolated islets and the early events related to insulin action in the hind-limb muscle of adult rats fed a diet of 17% protein (control) or 6% protein [low (LP) protein] during fetal life, suckling and after weaning, and in rats receiving 6% protein during fetal life and suckling followed by a 17% protein diet after weaning (recovered). The basal and maximal insulin secretion by islets from rats fed LP diet and the basal release by islets from recovered rats were significantly lower than that of control rats. The dose-response curves to glucose of islets from LP and recovered groups were shifted to the right compared to control islets, with the half-maximal response (EC50) occurring at 16.9 +/- 1.3, 12.4 +/- 0.5 and 8.4 +/- 0.1 mmol/L, respectively. The levels of insulin receptor, as well as insulin receptor substrate-1 and phosphorylation and the association between insulin receptor substrate-1 and phosphatidylinositol 3-kinase were greater in rats fed a LP diet than in control rats. In recovered rats, these variables were not significantly different from those of the other two groups. These results suggest that glucose homeostasis is maintained in LP and recovered rats by an increased sensitivity to insulin as a result of alterations in the early steps of the insulin signal transduction pathway.
dc.description128
dc.description10
dc.description1643
dc.description1649
dc.languageen
dc.publisherAmer Inst Nutrition
dc.publisherBethesda
dc.publisherEUA
dc.relationJournal Of Nutrition
dc.relationJ. Nutr.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectinsulin secretion
dc.subjectinsulin receptor
dc.subjectinsulin receptor substrate-1
dc.subjectnutritional recovery
dc.subjectrats
dc.subjectReceptor Substrate-1
dc.subjectPhosphatidylinositol 3-kinase
dc.subjectGlucose-tolerance
dc.subjectFatty-acid
dc.subjectMalnutrition
dc.subjectFetal
dc.subjectDiet
dc.subjectPhosphorylation
dc.subjectResistance
dc.subjectTransport
dc.titleProtein deficiency and nutritional recovery modulate insulin secretion and the early steps of insulin action in rats
dc.typeArtículos de revistas


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